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The current literature on the effects of clozapine on pregnancy is limited, and no cases of pregnant Japanese women have been reported. Decreased variability in the fetal heart rate due to clozapine exposure has been reported in countries other than Japan, but its association with serum concentrations of clozapine has not been documented. In this case, a 29-year-old Japanese primipara with treatment-resistant schizophrenia taking clozapine 250 mg/day experienced pregnancy. The pregnancy progressed without complications. At 40 weeks and 2 days of gestation, the patient developed premature rupture of membranes, and decreased variability in the fetal heart rate and variable deceleration were observed, leading to an emergency cesarean section. The neonate had no congenital malformations, metabolic disorders, seizures, floppy infant syndrome, leukopenia, or neutropenia. Serum concentrations of clozapine and norclozapine (N-desmethylclozapine), measured in the mother and in the neonate immediately after birth, suggested that clozapine and norclozapine were transported to the fetus during pregnancy. Based on these observations, the present case suggests that high fetal serum concentrations of clozapine and norclozapine may affect fetal heart rate. This case report concludes that, with careful monitoring, Japanese women taking clozapine can deliver successfully and emphasizes the importance of monitoring serum clozapine concentrations and fetal cardiac function throughout pregnancy, with particular attention to the later stages.
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BACKGROUND: In Japan, the mortality rate of extremely low birth weight (ELBW) infants is notably low in comparison with other developed countries, but the prevalence of chronic lung disease (CLD) and retinopathy of prematurity (ROP) is relatively high. This study aimed to estimate the mortality and morbidity of ELBW infants born in 2015 who were admitted to neonatal intensive care units (NICUs) in Japan and to examine the factors that affected the short-term outcomes of these infants. We also compared the mortality of ELBW infants born in 2005, 2010, and 2015. METHODS: We analyzed the mortality, morbidity, and factors related to short-term outcomes of ELBW infants, using data from 2782 infants born in 2015 and registered at NICUs in Japan. RESULTS: The mortality rates during NICU stays were 17.0%, 12.0%, and 9.8% for ELBW infants born in 2005, 2010, and 2015, respectively. Among ELBW infants born in 2015, multiple logistic regression analysis showed that short gestational age and low birthweight Z-score contributed to the increased risk of death. Births by cesarean section and antenatal corticosteroid administration were significantly associated with a reduced risk of death. Among infants who survived, CLD was observed in 53.1% and ROP requiring treatment was observed in 30.4%. CONCLUSIONS: Mortality in ELBW infants decreased significantly from 2005 to 2015. As CLD and ROP may affect quality of life and long-term outcomes of infants who survived, prevention strategies and management for these complications are critical issues in neonatal care in Japan.
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Mortalidad Infantil , Recien Nacido con Peso al Nacer Extremadamente Bajo , Cesárea , Morbilidad , Japón/epidemiología , Retinopatía de la Prematuridad/epidemiología , Prevalencia , Lesión Pulmonar/epidemiología , Humanos , Masculino , Femenino , Calidad de VidaRESUMEN
BACKGROUND: There are currently no definitive guidelines regarding newborns born to mothers with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to investigate the medical care and management that provided or would provide for such newborns. METHODS: A web survey was conducted between September and October 2020. A total of 624 hospitals, which generally accept pregnant women for delivery, were involved in this study. The survey included the number of newborns born to mothers with confirmed SARS-CoV-2 infection and evaluated policies regarding the medical care and management of newborns born to mothers with confirmed or suspected SARS-CoV-2 infection. RESULTS: Pregnant women with confirmed or suspected SARS-CoV-2 infection were accepted or planned to be accepted in 54% (334) of the hospitals. Out of 52 newborns born to mothers with confirmed SARS-CoV-2 infection, SARS-CoV-2 RNA was detected from the nasopharyngeal swab of one newborn shortly after birth. The types of personal protective equipment during the delivery, the separation of the newborns from the mothers, the SARS-CoV-2 testing methods, and the use of incubators during the quarantine period were uniformly provided. However, the methods of ventilator treatment in the event of respiratory disorders, feeding during maternal isolation, and de-quarantine and discharge criteria varied. CONCLUSIONS: This survey demonstrated that one newborn detected a SARS-CoV-2 RNA shortly after birth out of 52 newborns who were born to mothers with confirmed SARS-CoV-2 infection. The policies regarding medical care and management for these newborns in Japan were provided.
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COVID-19 , Complicaciones Infecciosas del Embarazo , Prueba de COVID-19 , Femenino , Humanos , Recién Nacido , Transmisión Vertical de Enfermedad Infecciosa , Japón/epidemiología , Madres , Embarazo , Complicaciones Infecciosas del Embarazo/diagnóstico , Complicaciones Infecciosas del Embarazo/epidemiología , Complicaciones Infecciosas del Embarazo/terapia , ARN Viral , SARS-CoV-2RESUMEN
We reconstructed the Blauth-IIIB hypoplastic right thumb of a 16-year-old girl with a vascularised metatarso-phalangeal (MTP) joint from her second toe combined with a dorsalis-pedis flap. Abduction was provided with an abductor policis long tendon advancement, and adduction, with an extensor indicis proprius tendon transfer. Opponoplasty was performed one year later using the flexor sublimis (IV) tendon. The transferred joint remained functional and non-osteoarthritic 28 years later. Radial and palmar abduction of the reconstructed thumb was 45 degrees and 75 degrees respectively. The index, middle, and ring fingers could oppose the thumb, however she grasped small objects between her index and middle fingertips. If a pollicisation using the index finger is not accepted, the reconstruction described here is one of the surgical options. However donor-foot morbidity is not negligible. Currently, we use a proximal-interphalangeal joint transfer with an opponoplasty using an abductor digiti minimi as a first choice, when planning a reconstruction of preserved hypoplasic thumb.
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Procedimientos de Cirugía Plástica/métodos , Pulgar/anomalías , Pulgar/cirugía , Dedos del Pie/trasplante , Adolescente , Femenino , Humanos , Colgajos QuirúrgicosRESUMEN
PURPOSE: We investigated the effect of severity and form of mutilating hand injuries on functional recovery and return to work, and the usefulness of an injury-severity score in predicting these outcomes. METHODS: We reexamined patients in whom finger amputation or near amputation had been treated with replantation or revascularization at our institution at least 3 years earlier. We evaluated radiographs, sensory recovery, finger range of motion, skin temperature, and current overall hand function to calculate Tamai and Quick Disabilities of the Arm, Shoulder, and Hand scores, and recorded return-to-work status, duration of treatment, and time away from work. We determined injury level, number of involved fingers, type of injury, and Campbell's Hand Injury Severity score (HISS) from the medical record. RESULTS: The average age of the 50 enrolled patients was 43 years (range, 18-69 years); average follow-up was 7.8 years (range, 3.1-15.3 years). More proximal injuries, more involved fingers, and more complicated injury predicted poorer functional recovery. HISS was highly correlated with Tamai's score (r = -0.77; p<.001) and moderately correlated with the Quick Disabilities of the Arm, Shoulder, and Hand score (r = 0.39; p = .009). HISS was only moderately correlated with length of treatment (r = 0.32; p<.05) and with time away from work (r = 0.34; p<.05). Mean HISS among the 3 return-to-work groups differed remarkably. When HISS was <50, 11 of 12 patients returned to their original jobs; when it was between 50 and 150, 17 of 23 patients were able to return; and when it was >150, only 4 of 15 were able to return to work. CONCLUSIONS: Given the current surgical care of patients with mutilated hand injuries, HISS determined at the time of injury can adequately predict functional outcome and return to work status. Larger studies will be necessary to validate these findings.
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Accidentes de Trabajo , Amputación Traumática/cirugía , Traumatismos de los Dedos/cirugía , Dedos/irrigación sanguínea , Puntaje de Gravedad del Traumatismo , Isquemia/cirugía , Recuperación del Miembro/rehabilitación , Complicaciones Posoperatorias/rehabilitación , Rehabilitación Vocacional , Reimplantación/rehabilitación , Adolescente , Adulto , Anciano , Evaluación de la Discapacidad , Femenino , Dedos/inervación , Estudios de Seguimiento , Humanos , Masculino , Microcirugia/métodos , Persona de Mediana Edad , Pronóstico , Reproducibilidad de los Resultados , Estudios Retrospectivos , Umbral Sensorial/fisiología , Colgajos Quirúrgicos/irrigación sanguínea , Colgajos Quirúrgicos/inervación , Adulto JovenRESUMEN
We report on a 28-week infant with growth restriction starting after 23 weeks' gestation because of measles virus (MV) infection of the mother. Histological findings for the placenta revealed extensive fibrin deposition and necrosis of the villi, and MV antigen was demonstrated in the syncytiotrophoblast by immunostaining. The MV-specific IgM level in the infant was negative, but that of the mother was positive. Therefore, we speculate that growth restriction is not attributed to direct infection with MV, but to placental dysfunction due to a decrease in intravillous blood flow and oxygen supply to the fetus.
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Retardo del Crecimiento Fetal/diagnóstico , Sarampión/diagnóstico , Complicaciones Infecciosas del Embarazo/diagnóstico , Adulto , Diagnóstico Diferencial , Femenino , Retardo del Crecimiento Fetal/complicaciones , Retardo del Crecimiento Fetal/diagnóstico por imagen , Retardo del Crecimiento Fetal/patología , Humanos , Recién Nacido , Masculino , Sarampión/complicaciones , Sarampión/patología , Embarazo , Complicaciones Infecciosas del Embarazo/patología , Segundo Trimestre del Embarazo , Ultrasonografía PrenatalRESUMEN
PURPOSE: Functional outcomes of cubital tunnel surgery may decline as the severity of preoperative ulnar neuropathy increases. When functional recovery will be adequate, or whether tendon transfers should be required, may be unclear. We investigated the extent of functional recovery, the duration of the recovery process, and the necessity of restoring intrinsic muscle function in patients with severe cubital tunnel syndrome after surgery. METHODS: We retrospectively studied outcomes after cubital tunnel release in 15 patients with marked intrinsic muscle atrophy, claw-hand deformity, immeasurable (electrically silent) sensory and motor nerve conduction velocities, and Semmes-Weinstein test (SWT) results ranging from purple (3.84-4.31) to red (4.56-6.65). We evaluated subjective (numbness and activities of daily living [ADL] disturbances), objective (manual muscle testing [MMT] of index-finger abduction, and SWT), and neurophysiologic (nerve conduction velocity) outcomes. Overall functional outcome was evaluated by Akahori's criteria. RESULTS: At a median follow-up evaluation of 4.5 years all outcomes had improved. Numbness was gone in 5 patients and greatly reduced in 9 patients; 6 patients reported slight difficulties in ADLs; and 9 patients had no difficulties. Motor nerve conduction velocity was measurable (mean, 35.3 m/s) in all 15 patients and sensory nerve conduction velocity was measurable (mean, 43.4 m/s) in 12. Recoveries in nerve conduction velocities persisted beyond 2 years. The SWT results were blue (3.22-3.61) in 6 patients, purple (3.84-4.31) in 8 patients, and red (4.56-6.65) in 1 patient. MMT of index finger abduction was grade 4 or 5 in 11 of 15 patients. Half the patients over 70 years old, however, were grade 3 or less. Akahori's criteria were excellent in 3 patients, good in 6 patients, and fair in 6 patients. CONCLUSIONS: Patients with severe intrinsic muscle atrophy and absent motor and sensory nerve conduction velocities can expect satisfactory long-term functional results after surgery. Function continues to improve beyond 2 years. Restoring index finger abduction is not always necessary for ADLs, although recovery requires several years and is poorer in the elderly.