RESUMEN
The effect of two types of low-energy laser radiation (He-Ne and infrared) was investigated. Both types had the same effect: stimulation of the liver regeneration due to active proliferation of the tetraploid and binuclear hepatocytes.
Asunto(s)
Rayos Láser , Regeneración Hepática/efectos de la radiación , Hígado/citología , Ploidias , Animales , División Celular/efectos de la radiación , Hígado/efectos de la radiación , Regeneración Hepática/fisiología , RatasRESUMEN
To specify the role porphyrins play in the development of diffuse liver injuries, 53 patients with alcohol-induced liver injuries were examined. Of these, 17 patients manifested marked derangement of porphyrin metabolism. As a result of clinico-biochemical, immunological and morphological research methods, it is established that marked derangement of porphyrin metabolism manifesting itself in porphyrin deposition in hepatocytes and in the high level of uro and coproporphyrinuria is associated with the development of autoimmune reactions towards liver-specific lipoprotein, which determines the development of the grave forms of liver injury in patients who abuse alcohol.
Asunto(s)
Hepatopatías Alcohólicas/metabolismo , Porfirinas/fisiología , Adulto , Coproporfirinas/orina , Femenino , Humanos , Hepatopatías Alcohólicas/inmunología , Masculino , Persona de Mediana Edad , Uroporfirinas/orinaRESUMEN
It is shown that the activity of the disease depends on the localisation of HBsAg and HBcAg in the hepatocyte and on the reaction of the delayed hypersensitivity (RDH) to HBsAg and liver-specific lipoprotein (LSL). RDH to HBsAg, LSL and a diffuse localisation of HBsAg in the hepatocyte cytoplasm are observed in the non-active chronic diffuse liver disease while the marginal or membraneous localisation of HBsAg which is frequently combined with HBcAg in nuclei and RDH to HBsAg and LSL are found in the active forms of chronic liver diseases.
Asunto(s)
Virus de la Hepatitis B/inmunología , Hepatopatías/inmunología , Hígado/inmunología , Proteínas de la Membrana , Biomarcadores/análisis , Biopsia , Enfermedad Crónica , Anticuerpos contra la Hepatitis B/análisis , Antígenos del Núcleo de la Hepatitis B/análisis , Antígenos de Superficie de la Hepatitis B/análisis , Humanos , Hipersensibilidad Tardía/inmunología , Hipersensibilidad Tardía/patología , Lipoproteínas/inmunología , Hígado/patología , Hepatopatías/patología , Proteínas/inmunologíaRESUMEN
It is established that the liver tissue of HBs antigen carriers, apart from the persistence of two hepatitis B virus antigens, contains morphological alterations ranging from the benign hyperbilirubinemia to the minimal and chronic persisting hepatitis. The authors claim that the minimal structural liver alterations in these patients are due to the tolerance of the immunocompetent system and deficiency of the macrophageal function of star-like endotheliocytes.
Asunto(s)
Portador Sano/patología , Antígenos de Superficie de la Hepatitis B/análisis , Hepatitis B/patología , Hígado/patología , Adulto , Biopsia con Aguja , Portador Sano/inmunología , Femenino , Técnica del Anticuerpo Fluorescente , Hepatitis B/inmunología , Anticuerpos contra la Hepatitis B/análisis , Antígenos del Núcleo de la Hepatitis B/análisis , Humanos , Hiperbilirrubinemia/inmunología , Hiperbilirrubinemia/patología , Hígado/inmunología , Masculino , Persona de Mediana EdadRESUMEN
Eighty-eight asymptomatic HBsAg carriers were examined for cellular and humoral immunity and markers of virus B hepatitis in liver tissue and blood serum. The following results were obtained: HBsAg and HBcAg in liver tissue were found in 10 and 19 out of the 24 examinees, respectively, HBeAg and anti-Hbe in blood serum in 2 and 20 out of the 25 examinees, respectively. No alterations were recorded on the part of humoral immunity. Changes in cellular immunity manifested themselves by reduction in the number of T lymphocytes, and decreased response to PHA. Sensitization to HBsAg led to the purification of hepatitis B virus whereas the presence of simultaneous sensitization to liver-specific lipoprotein contributed to development of graver patterns of liver injury. The role of the immune system and hepatitis B virus itself in the pathogenesis of liver injury in asymptomatic HBsAg carriers is discussed.