RESUMEN
The paper describes synthesis and antibacterial study of biologically active Mannich bases of carboxamide derivative employing Mannich reaction of 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide with various sulfonamides/secondary amines . They were analysed by elemental analysis and characterized by UV, IR and (1)H NMR spectroscopic studies. The Mannich bases were screened for antibacterial activity against various gram-negative bacteria at various concentrations and were analysed statistically. The result has shown that the compounds are quite active against pathogens under study and were non-toxic. All the synthesized compounds were found to be low lethal as ascertained by LD50 test.
Asunto(s)
Antibacterianos/síntesis química , Antibacterianos/farmacología , Bases de Mannich/síntesis química , Naftacenos/síntesis química , Animales , Antibacterianos/toxicidad , Indicadores y Reactivos , Dosificación Letal Mediana , Espectroscopía de Resonancia Magnética , Bases de Mannich/toxicidad , Ratones , Naftacenos/farmacología , Pasteurella multocida/efectos de los fármacos , Salmonella enteritidis/efectos de los fármacos , Espectrofotometría Infrarroja , Espectrofotometría UltravioletaRESUMEN
Biologically active Mannich bases with heteroaromatic ring system have been synthesised employing Mannich reaction of isonicotinyl hydrazide with various sulphonamides/secondary amines. They were analysed by elemental analysis and characterized by uv, ir, 1H nmr spectroscopic studies. The Mannich bases were screened for their antibacterial activity against various gram positive and gram negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.