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CONTEXT: India has a high perinatal mortality rate. The Indian Radiological and Imaging Association (IRIA) is supplementing efforts to address perinatal mortality in India through the Samrakshan program. AIMS: To describe various elements of the Samrakshan program that aims to reduce perinatal mortality in India. METHODS: Samrakshan focuses on two priority areas, preeclampsia (PE) and fetal growth restriction (FGR). Samrakshan aims at technical skill upgradation, specifically focused on improved interpretative ability, prognostic and therapeutic efficacy using Doppler studies, a free online learning platform and offline continuous medical educations (CMEs), building an evidence base from the program to develop policy and guidelines, and improving synergy with the RAKSHA program of IRIA and other fetal care stakeholders. RESULTS: Two courses on Doppler studies focused on first trimester and third trimester, supplemented by case discussions and journal articles, have started on the online platform with 230 registrants. The first statewide CME was held at Indore. Samrakshan screening identified 10 (17.24%, 95% CI: 8.59, 29.43) women at high risk for preterm PE and 29 (50.00%, 95% CI 36.58, 63.42) women at high risk for FGR in the first trimester. Ten fetuses (7.63%, 95% CI: 3.72, 13.59) including 9 with stage 1 FGR were identified in the third-trimester screening. CONCLUSIONS: Samrakshan is a flagship program of IRIA that aims to reduce perinatal mortality in India through a synergistic, holistic approach that complements and supplements existing efforts in India.
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The present study was undertaken to evaluate in vivo anti-aggressive potential of a standardized extract of Marsilea minuta Linn. (Marsileaceae). The standardized extract of Marsilea minuta was evaluated for its potential effects against defensive and offensive aggressive behavior models of rodents. Marsilea minuta extract was orally administered at three dose levels (100, 200, and 400 mg/kg BW) once daily for 14 consecutive days as a suspension in polyethylene glycol (PEG), diazepam (2.5 mg/kg, p.o.) was used as a standard anti-aggressive agent. Control group animals were given an equal volume of vehicle (10%, v/v, PEG suspension). Anti-aggressive activity was evaluated using the following validated models of aggression, viz.: foot shock-induced aggression, isolation-induced aggression and resident-intruder aggression, in rodents. As a result, Marsilea minuta extract showed dose dependant anti-aggressive activity in the aforementioned, validated models of aggression. This suggests that the extract from Marsilea minuta has a promising anti-aggressive activity qualitatively comparable to that of diazepam.