Asunto(s)
Bazo/lesiones , Heridas por Arma de Fuego/cirugía , Heridas Punzantes/cirugía , Traumatismos Abdominales/mortalidad , Traumatismos Abdominales/cirugía , Adolescente , Adulto , Anciano , Urgencias Médicas , Femenino , Humanos , Masculino , Persona de Mediana Edad , Traumatismo Múltiple/mortalidad , Traumatismo Múltiple/cirugía , Bazo/trasplante , Esplenectomía , Trasplante Autólogo , Heridas por Arma de Fuego/mortalidad , Heridas no Penetrantes/mortalidad , Heridas no Penetrantes/cirugía , Heridas Punzantes/mortalidadRESUMEN
The influence of immune antistaphylococcal, anti-Proteus and anti-Pseudomonas aeruginosa plasma and donor leukocyte mass on some humoral and cell-mediated immunity characteristics in patients with purulent and septic diseases has been studied. The study has shown that treatment with immune plasma leads to an increase in the amount of circulating T lymphocytes and in the concentration of IgA, IgM and IgG, to the activation of phagocytosis and to an increase in the titers of the corresponding antimicrobial antibodies simultaneously with a decrease in the content of bacterial antigens in the blood serum. Treatment with donor leukocyte mass has also been found to lead to an increase in the concentration of T lymphocytes and immunoglobulins, to enhance the functional activity of phagocytizing neutrophils and to promote the normalization of the content of leukocytes in the peripheral blood. The use of these preparations as stimulating agents in the treatment of patients having purulent septic diseases and, simultaneously, low cell-mediated immunity characteristics is recommended.
Asunto(s)
Donantes de Sangre , Leucocitos/inmunología , Plasma/inmunología , Proteus mirabilis/inmunología , Pseudomonas aeruginosa/inmunología , Staphylococcus aureus/inmunología , Supuración/terapia , Anticuerpos Antibacterianos/análisis , Formación de Anticuerpos/efectos de los fármacos , Formación de Anticuerpos/inmunología , Antígenos Bacterianos/análisis , Humanos , Inmunidad Celular/efectos de los fármacos , Inmunidad Celular/inmunología , Inmunoterapia/métodos , Supuración/inmunología , Factores de TiempoRESUMEN
The use of polyvalent erythrocyte diagnosticum prepared on the basis of 5 polysaccharide antigens of P. aeruginosa slime, isolated from strains belonging to the most widespread serovars, makes it possible to check up the humoral response of donors after their immunization with P. aeruginosa polyvalent corpuscular vaccine with the aim of obtaining anti-P. aeruginosa donor plasma. Antibody titers, determined in the passive hemagglutination test with the use of the proposed diagnosticum and corresponding to a serum dilution of 1:320 and greater, age tentatively diagnostic, which may be indicative of P. aeruginosa in the development of purulent septic complications in patients. The use of the passive hemagglutination test with the newly developed polyvalent erythrocyte diagnosticum makes it possible to check up the specific response of patients having P. aeruginosa infection in the process of their treatment with anti-P. aeruginosa hyperimmune plasma used as a part of complex therapy.
Asunto(s)
Anticuerpos Antibacterianos/análisis , Eritrocitos/inmunología , Infecciones por Pseudomonas/diagnóstico , Pseudomonas aeruginosa/inmunología , Especificidad de Anticuerpos , Vacunas Bacterianas/inmunología , Donantes de Sangre , Quemaduras/inmunología , Pruebas de Hemaglutinación/métodos , Humanos , Heridas y Lesiones/inmunologíaRESUMEN
The influence of immunization with P. aeruginosa vaccine on the immune status of volunteer donors has been studied. Immunization with P. aeruginosa vaccine in doses of 0.5-0.5-1.0 ml at intervals of 7 days has been found to lead to the 13-fold increase of the titer of specific antibodies, lasting for 3-4 months, which ensures the possibility of obtaining anti-P. aeruginosa hyperimmune plasma with standard titers. The injection of P. aeruginosa vaccine to donors leads to the activation of humoral immunity simultaneously with the increase of the absolute and relative number of rosette-forming B-lymphocytes without essential changes in the amount of rosette-forming T-lymphocytes.
Asunto(s)
Vacunas Bacterianas/inmunología , Inmunización , Pseudomonas aeruginosa/inmunología , Adulto , Anticuerpos Antibacterianos/análisis , Formación de Anticuerpos , Vacunas Bacterianas/aislamiento & purificación , Relación Dosis-Respuesta Inmunológica , Humanos , Inmunidad Celular , Inmunidad Innata , Inmunización/métodos , Recuento de Leucocitos , Factores de TiempoRESUMEN
Specific features of the clinical course of odontogenous mediastinitis, development of complications, diagnosis, surgical methods are discussed by the authors on the basis of their experience with the treatment of 12 patients with this disease. The significance of complex treatment is stressed which must include the purposeful specific immunotherapy and oxygenic barotherapy in addition to surgical methods, antibiotics and detoxication. One of 12 patients died due to arrosive bleeding from the common carotid artery and jugular vein. Eleven patients recovered.
Asunto(s)
Infección Focal Dental/complicaciones , Mediastinitis/terapia , Infecciones Estafilocócicas/terapia , Infecciones Estreptocócicas/terapia , Adulto , Antibacterianos/uso terapéutico , Antiinfecciosos Locales/uso terapéutico , Terapia Combinada , Drenaje , Humanos , Oxigenoterapia Hiperbárica , Masculino , Mediastinitis/etiología , Persona de Mediana Edad , Irrigación TerapéuticaRESUMEN
In the treatment of 34 patients with suppurative mediastinitis a specific immune therapy was used in addition to surgical methods. Direct specific immune therapy as an element of the complex treatment of suppurative mediastinitis resulted in a more favourable development of the process and reduced lethality.