RESUMEN

We studied the effect of Vilon in rats 2, 4, and 6 months after the onset of chronic renal failure. Subcutaneous injection of Vilon significantly decreased serum concentration of transforming growth factor-beta(1) and permeability of mesenteric microvessels in rats 2 months after the onset of chronic renal failure. Our results indicate that the preparation produces a potent homeostatic effect in the early period of chronic renal failure.

Asunto(s)

Permeabilidad Capilar/efectos de los fármacos , Dipéptidos/farmacología , Endotelio Vascular/efectos de los fármacos , Fallo Renal Crónico/sangre , Factor de Crecimiento Transformador beta/sangre , Animales , Capilares/citología , Dipéptidos/uso terapéutico , Fallo Renal Crónico/tratamiento farmacológico , Fallo Renal Crónico/metabolismo , Masculino , Arteria Mesentérica Inferior/citología , Arteria Mesentérica Inferior/efectos de los fármacos , Ratas