RESUMEN
The summary of the study is that when using both medicines indraline doesn't influence the effectiveness of pherrocine in preventing of 137Cs accumulation in the main depositing/pooling organs. The radiation protecting medicine indraline used more intensive accumulation of radio nuclides in liver and kidney then a control. Accumulation rapidity and amount of 137Cs in liver and kidney depends on the time period between taking indraline and inflow of cesium into organism of animals. For the case when animals being exposured by external gamma-irradiation and incorporation of 137Cs the introduction of indraline without pherrocine is not advisable.
Asunto(s)
Antídotos/uso terapéutico , Ferrocianuros/uso terapéutico , Rayos gamma , Fenoles/uso terapéutico , Traumatismos por Radiación/tratamiento farmacológico , Protectores contra Radiación/uso terapéutico , Administración Oral , Animales , Animales no Consanguíneos , Radioisótopos de Cesio/metabolismo , Radioisótopos de Cesio/toxicidad , Vías de Administración de Medicamentos , Quimioterapia Combinada , Enteroadsorción , Inyecciones Intramusculares , Riñón/metabolismo , Hígado/metabolismo , Masculino , Ratones , Ratones Endogámicos CBA , Músculo Esquelético/metabolismoRESUMEN
An attempt to evaluate the influence of tritium oxide on the metabolism by some indices of lipid metabolism (common lipids, beta-lipoproteins, cholesterin), protein metabolism (cholinesterasa) and carbohydrate metabolism (blood sugar) was made. It was established that the introduction into organism of tritium oxide in the quantities, which could form lethal and sublethal doses of internal radiation, provoked the main changes of values of mentioned indices of metabolism. The character of metabolism changes in the remote period allows us to judge about the development of sclerosis processes, which can be the result of radiation-stipulated acceleration of organism aging.
Asunto(s)
Glucemia/metabolismo , Colinesterasas/metabolismo , Metabolismo de los Lípidos , Tritio/administración & dosificación , Agua/administración & dosificación , Animales , Perros , Inyecciones Intraperitoneales , Factores de TiempoRESUMEN
The influence of tritium oxide injected peritoneally of the range of activity of 5.5 MBq/g to 111 MBq/g versus gamma-radiation of 137Cs with decreasing dose rate in biochemical parameters of blood in rats was compared. It was shown that relative biological effectiveness of tritium oxide was higher than that for metabolism and it was equal to 1.5 in average.