RESUMEN
This study sought to evaluate seizure-related injuries in children under age 18 years with newly diagnosed epilepsy presenting at the Department of Pediatrics, Tuen Mun Hospital, in 2002-2003. All children were interviewed before January 2005. Children with seizure-related injuries were compared with those without injuries for identification of risk factors. One hundred and twenty-two children were surveyed. No patient died during a seizure. Eleven (9%) children manifested seizure-related injuries. Injury occurred at a mean age of 11.6 years, and epilepsy was diagnosed at a mean age of 13.8 years, in those with seizure-induced injuries. Injury occurred at first seizure presentation or upon diagnosis of epilepsy in 72.7% patients. Ten (90.9%) children were not receiving antiepileptic drugs at their time of injury. The mean age of seizure onset was 10.7 years in patients with injuries, and 6.7 years in control subjects (P = 0.007). Seizures resulting in injuries were generalized tonic-clonic in 72.7% (P = 0.045; odds ratio, 3.77; 95% confidence interval, 0.95-14.98). Idiopathic etiology was evident in 54.5%, and normal neurodevelopmental status in 72.7%, of patients with injuries. Age of seizure onset was the only independent variable retained after multivariate analysis. Soft-tissue and dental injuries comprised 91.7% and 75%, respectively, of injuries occurring at home. The risk of seizure-related injuries was substantial, especially before epilepsy was diagnosed, but most of these injuries were minor. These unique data could help in parental counseling.
Asunto(s)
Accidentes , Epilepsia/complicaciones , Convulsiones/complicaciones , Adolescente , Edad de Inicio , Niño , Preescolar , Epilepsia/diagnóstico , Femenino , Humanos , Lactante , Masculino , Oportunidad Relativa , Selección de Paciente , Factores de Riesgo , Convulsiones/diagnósticoRESUMEN
Hospitalizations due to breakthrough seizures were studied in children with newly diagnosed epilepsy to evaluate (1) risk factors associated with such admissions, in particular the withholding of medication and subtherapeutic dose of anticonvulsants, and (2) the impact of the unscheduled hospitalization on subsequent seizure outcome. We recruited patients aged less than 18 years with newly diagnosed epilepsy who presented to the pediatric department in Tuen Mun Hospital between January 2002 and December 2003. Patients with acute seizure-related hospitalization within 1 year after diagnosis were included as cases (n = 36); patients with no such hospitalization were included as controls (n = 86). Treatment effect was analyzed at the last follow-up visit before January 2005. Significant univariate association was observed between seizure-related hospitalization and age at seizure onset (OR = 0.91, 95% CI 0.84, 1), idiopathic epilepsy (OR = 0.35, 95% CI 0.15, 0.81), no antiepileptic drug (OR = 3.67, 95% CI 1.51, 8.18), and subtherapeutic doses of antiepileptic drug (OR = 9.9, 95% CI 2.2, 43.8). Independent risk factors of such hospitalizations were etiology of epilepsy, no antiepileptic drug, subtherapeutic dose of antiepileptic drug, and history of febrile convulsion. Sixty-four percent of the cohort was seizure-free. Acute seizure-related hospitalization was associated with less favorable outcome (OR = 3.79, 95% CI 1.48, 9.26).