RESUMEN
Possible local application of a new dosage form of bleomycetin (bleomycin) with the prolonged action was studied in experimental in vivo models. When the ion exchange textile polymer with the immobilized bleomycetin was implanted subcutaneously to tumor-bearing mice, there was observed marked inhibition of the growth of the following tumors: lung carcinomatosis (LLC), melanoma B-16 and lympholeukemia (NK/Ly). The implants proved to be less toxic by comparison to bleomycetin solutions. The new bleomycetin dosage form is useful as a new delivery system increasing the antibiotic selective action.
Asunto(s)
Antibióticos Antineoplásicos/administración & dosificación , Vendajes , Bleomicina/análogos & derivados , Adsorción , Animales , Bleomicina/administración & dosificación , Carcinoma/tratamiento farmacológico , Implantes de Medicamentos , Transporte Iónico/efectos de los fármacos , Leucemia Experimental/tratamiento farmacológico , Leucemia Linfoide/tratamiento farmacológico , Neoplasias Pulmonares/tratamiento farmacológico , Masculino , Melanoma Experimental/tratamiento farmacológico , Ratones , Ratones Endogámicos C57BL , Trasplante de NeoplasiasRESUMEN
Bleomycetin, an antitumor antibiotic of the domestic origin, is component A5 of the bleomycin complex. Design of new drug delivery systems especially for local application is an important problem of antitumor chemotherapy. Bleomycetin immobilized on ion exchange medical gauze was studied with this purpose in an in vivo experimental model of murine lympholeukemia NK/Ly. Subcutaneous implantation of the new dosage form of bleomycetin with prolonged action provided a significant antitumor systemic effect evident from an increase in the mouse life-span. In vitro determination of the bleomycetin contents in the gauze revealed that the antibiotic was completely absorbed from the carrier within 72 hours. The bleomycetin half-life in the plasma after the antibiotic administration in the bound form on the ion exchange gauze was twice as long as that after the antibiotic injection with NaCl isotonic solution.