RESUMEN
Levels of immunoglobulins G, A and M and complement factor C3 and C4 were determined by single radial immunodiffusion techniques in a group of 26 children with a history of postinfectious thrombocytopenic purpura and in another group of 6 children with chronic ITP. The statistical evaluation of the data of patients with chronic ITP did not show any significant deviation from normal. In patients with previously acute, reversible ITP, levels of IgG and IgM were elevated. Whether this elevation was significant or not depended upon the statistical analysis applied. C3 levels tended to be above the average normal mean, C4 levels, in contrast, to be below. The importance of increased IgG and IgM concentrations in patients with the history of postinfectious ITP is discussed. The raised IgG and IgM levels are interpreted as an expression of a certain type of hyperimmune state rather than as an impairment of immunoregulatory mechanisms.
Asunto(s)
Proteínas del Sistema Complemento/análisis , Inmunoglobulinas/análisis , Púrpura Trombocitopénica/inmunología , Trombocitopenia/inmunología , Adolescente , Niño , Preescolar , Complemento C3/análisis , Complemento C4/análisis , Femenino , Humanos , Inmunoglobulina A/análisis , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Masculino , Trombocitopenia/etiologíaRESUMEN
26 patients with an acute reversible ITP and 6 with chronic ITP were tissue typed, together with their healthy first-degree relatives. The HLA frequencies of the different groups were compared with those of a normal control population. The only significant difference between the groups was an increase in the frequency of Aw32 in acute ITP patients. HLA-Aw32 was present in 26.9% of patients, but in only 0.8% of the controls (corrected P = 0.000027). The possible importance of associations between antigens of the HLA-A locus with certain diseases are discussed. Family analyses and haplotype determinations proved to be unproductive because no familial clustering of ITP was found.