RESUMEN
OBJECTIVES: To examine the onset signs, clinical course, prognosis, treatment and outcome of Adamantiades-Behçet's disease in adult Greek patients during a 10-year follow-up period, and to compare the results with those of other series reported. METHODS: The studied population consisted of 82 adult patients (54 male and 28 female) of Greek origin. Patients filled out a standard questionnaire and were followed up regularly. The findings during the follow-up of these patients were compared with those of other series. RESULTS: The most frequent onset sign was oral aphthae, both in our patients and in those of other published series. Eye involvement, joint involvement, genital ulcers and skin lesions followed in frequency. During a 10-year follow-up differences were observed between men and women, with arthritis being more frequent in females compared to males and with an overall more severe course in males. Eye involvement occurred earlier than neurological and vascular manifestations. A few differences were found in the clinical parameters in comparison to previously reported ethnic series. HLA-B51 positive patients presented an odds ratio of 9.5, the activity index was 5.17 +/- 2.56 and the mean severity score 5.96 +/- 2.32. Early treatment led to improvement of the disease. CONCLUSION: The pattern of Adamantiades-Behçet's disease in adult Greek patients provides major similarities when compared to patterns in various other national groups.
Asunto(s)
Síndrome de Behçet/diagnóstico , Síndrome de Behçet/epidemiología , Adulto , Distribución por Edad , Anciano , Síndrome de Behçet/terapia , Estudios de Cohortes , Terapia Combinada , Femenino , Grecia/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Probabilidad , Pronóstico , Medición de Riesgo , Índice de Severidad de la Enfermedad , Distribución por SexoRESUMEN
We have examined the presentation of low back pain in three patients with ochronosis, and have reviewed the literature. Low back pain and/or stiffness is the first presenting feature and usually appears after the age of 30. Discolouration of the ear is almost always present. Characteristic radiographic changes in the lumbar spine include calcification of the intervertebral discs and lucencies in the discs. The process gradually extends to the entire spine.
Asunto(s)
Dolor de Espalda/etiología , Ocronosis/complicaciones , Dolor de Espalda/diagnóstico por imagen , Dolor de Espalda/genética , Calcinosis/diagnóstico por imagen , Diagnóstico Diferencial , Humanos , Disco Intervertebral/diagnóstico por imagen , Vértebras Lumbares/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Ocronosis/diagnóstico por imagen , Ocronosis/genética , RadiografíaRESUMEN
We report the case of a man with ankylosing hyperostosis of the spine who developed spastic quadriparesis due to ossification of the posterior longitudinal ligament. The related literature is discussed.