RESUMEN

Paracetamol (PCM)-loaded composite nanoparticles (NPs) composed of a biodegradable poly(d,l-lactide) (PLA) polymer matrix filled with organically modified montmorillonite (MMT) nanoparticles were fabricated by antisolvent nanoprecipitation in a microfluidic co-flow glass capillary device. The incorporation of MMT in the polymer improved both the drug encapsulation efficiency and the drug loading, and extended the rate of drug release in simulated intestinal fluid (pH 7.4). The particle size increased on increasing both the drug loading and the concentration of MMT in the polymer matrix, and decreased on increasing the aqueous to organic flow rate ratio. The drug encapsulation efficiency in the NPs was higher at higher aqueous to organic flow rate ratio due to faster formation of the NPs. The PCM-loaded PLA NPs containing 2 wt% MMT in PLA prepared at an aqueous to organic flow rate ratio of 10 with an orifice size of 200 µm exhibited a spherical shape with a mean size of 296 nm, a drug encapsulation efficiency of 38.5% and a drug loading of 5.4%. The encapsulation of MMT and PCM in the NPs was confirmed by transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis and attenuated total reflection-Fourier transform infrared spectroscopy.

Asunto(s)

Acetaminofén/farmacocinética , Bentonita/química , Vidrio/química , Microfluídica/métodos , Nanopartículas/química , Poliésteres/química , Acetaminofén/química , Analgésicos no Narcóticos/química , Analgésicos no Narcóticos/farmacocinética , Rastreo Diferencial de Calorimetría , Preparaciones de Acción Retardada/química , Preparaciones de Acción Retardada/farmacocinética , Portadores de Fármacos/química , Liberación de Fármacos , Concentración de Iones de Hidrógeno , Microscopía Electrónica de Transmisión , Nanopartículas/ultraestructura , Tamaño de la Partícula , Solventes/química , Espectrometría por Rayos X , Espectroscopía Infrarroja por Transformada de Fourier , Difracción de Rayos X

RESUMEN

In this article, liquid moisture transport behaviors of dual-layer electrospun nanofibrous mats are reported for the first time. The dual-layer mats consist of a thick layer of hydrophilic polyacrylonitrile (PAN) nanofibers with a thin layer of hydrophobic polystyrene (PS) nanofibers with and without interpenetrating nanopores, respectively. The mats are coated with polydopamine (PDOPA) to different extents to tailor the water wettability of the PS layer. It is found that with a large quantity of nanochannels, the porous PS nanofibers exhibit a stronger capillary effect than the solid PS nanofibers. The capillary motion in the porous PS nanofibers can be further enhanced by slight surface modification with PDOPA while retaining the large hydrophobicity difference between the two layers, inducing a strong push-pull effect to transport water from the PS to the PAN layer.