RESUMEN
We studied the intestinal flora of 23 newborns, whose meconium had yielded a pure culture of Pseudomonas aeruginosa on blood agar medium. Twelve infants had a single serotype of P. aeruginosa in their meconium, 10 had a second serotype and the last infant was carrying three distinct ones. The maximum levels of P. aeruginosa observed during the first week of life were variable among the infants: 1 x 10(3) to 1 x 10(10) CFU/g of stools. The levels diminished progressively afterwards, and after 1 year of age only 1 of the 13 infants examined remained a carrier of P. aeruginosa. In 11 infants a second or a third serotype occurred during the course of the study. The serotypes that appeared secondarily always disappeared before the initial ones. Antibiotics: ampicillin + gentamicin or cefotaxime + netilmicin and colistin which were given to 8 infants had no clear effect on P. aeruginosa levels. Four infants had delayed colonization by Escherichia coli of greater than or equal to 10 days. All 4 had high levels of P. aeruginosa: 1 x 10(7) to 1 x 10(10) CFU/g stool, and antibiotic therapy, rendering it impossible to assess which was the cause of this delay. This colonization by P. aeruginosa did not lead to any clinical trouble.
Asunto(s)
Recien Nacido Prematuro , Enfermedades Intestinales/microbiología , Infecciones por Pseudomonas/microbiología , Pseudomonas aeruginosa/aislamiento & purificación , Cefotaxima/uso terapéutico , Colistina/uso terapéutico , Quimioterapia Combinada , Escherichia coli/aislamiento & purificación , Heces/microbiología , Femenino , Gentamicinas/uso terapéutico , Humanos , Recién Nacido , Recién Nacido Pequeño para la Edad Gestacional , Enfermedades Intestinales/tratamiento farmacológico , Masculino , Meconio/microbiología , Netilmicina/uso terapéutico , Infecciones por Pseudomonas/tratamiento farmacológico , Serotipificación , Ticarcilina/uso terapéutico , Factores de TiempoRESUMEN
The in vitro antibacterial activity of cefotaxime and ceftriaxone-aminoglycoside combinations was studied against 20 clinical isolates of Listeria monocytogenes, and compared with the activity of the antibiotics alone. Minimal bacteriostatic and bactericidal concentrations (MBCs) as well as killing curves were determined using different parameters. In all cases, the MBCs of gentamicin and netilmicin were shown to be lowered by addition of CTX or CTR. Using Mueller-Hinton broth the values of MBCs obtained were achievable in the CSF. However, the clinical bearing of these results remained to be discussed.
Asunto(s)
Antibacterianos/farmacología , Cefotaxima/farmacología , Ceftriaxona/farmacología , Listeria monocytogenes/efectos de los fármacos , Aminoglicósidos/farmacología , Quimioterapia Combinada , Humanos , Recién NacidoRESUMEN
A case of trisomy 6p21 leads to 6pter resulting from a maternal balanced t(2;6)(p25;p21) translocation is reported. The main clinical abnormalities were psychomotor retardation, hypotrophy, blepharophimosis, nystagmus, high nasal bridge, small mouth, sacral dimple, and systolic murmur. Other anomalies might have been due to partial 2p monosomy. Comparison with seven other cases of trisomy 6p allowed the delineation of a clinical entity. Direct proof of the localization of HLA genes was given by the presence of three haplotypes in the index patient.
Asunto(s)
Anomalías Múltiples/genética , Cromosomas Humanos 6-12 y X , Trisomía , Homólogo de la Proteína Chromobox 5 , Cromosomas Humanos 1-3 , Femenino , Genes MHC Clase II , Trastornos del Crecimiento/genética , Antígenos HLA/genética , Humanos , Recién Nacido , Cariotipificación , Trastornos Psicomotores/genética , Translocación GenéticaRESUMEN
One case of mediastinal tuberculous lymph node with fistulae into the esophagus is reported in a 9 years old girl. The first symptom was the appearance of epigastric abdominal pain, with secondary dysphagia. The diagnosis was confirmed by histology after thoracotomy and surgical excision. Esophageal tuberculosis is rare and seems to be secondary to contamination from mediastinal lymph nodes. Treatment is always medical and often requires surgery.