RESUMEN
Forty-seven Danish and 50 Finnish patients with familial adenomatous polyposis coli (FPC) were studied by panoramic tomography (PTG) of the mandible, which showed dental abnormalities in 17% of the cases. Eleven patients (11%) had supernumerary teeth and/or compound osteomas, and nine patients (9%) had impacted permanent teeth. The frequency of the dental anomalies was statistically significantly higher in FPC patients than in the normal population; it is therefore concluded that this dental abnormality should be included in the list of extracolonic manifestations that may occur in any FPC patient. The frequency of dental anomalies was higher in Finnish than in Danish patients, probably owing to a higher frequency of extracolonic manifestations in the Finnish series.
Asunto(s)
Poliposis Adenomatosa del Colon/complicaciones , Anomalías Dentarias/complicaciones , Adolescente , Adulto , Anciano , Niño , Quiste Epidérmico/complicaciones , Femenino , Fibroma/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Diente Impactado/complicaciones , Diente Supernumerario/complicacionesRESUMEN
Orthopantomography of the mandible was carried out on 50 patients with colorectal adenoma(s) without carcinoma or any known familial disposition. Four patients (8%) had osteomas, and we advance the hypothesis that individuals with both osteomas and adenomas represent a separate type of adenoma patient. Further studies are needed to evaluate the prognostic value of the association of adenomas and mandibular osteomas.
Asunto(s)
Adenoma/diagnóstico , Neoplasias del Colon/diagnóstico , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Primarias Múltiples/diagnóstico , Osteoma/diagnóstico por imagen , Neoplasias del Recto/diagnóstico , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Radiografía PanorámicaRESUMEN
Orthopantomography of the mandible (OTM) showed osteomas in 3 of 34 non-affected sibs and children of the probands in 14 families with polyposis coli. The observed to expected ratio with osteomas was 0.35, which is not significantly lower than 1.0 and in accordance with the frequency in the normal population. Although the result does not enable a definite evaluation of the diagnostic value of OTM, the finding suggests that this method may be used as a supplement to regular proctosigmoidoscopic screening of first-degree relatives of polyposis patients.
Asunto(s)
Adenoma/genética , Neoplasias del Colon/genética , Neoplasias Mandibulares/genética , Neoplasias Primarias Múltiples/genética , Osteoma/genética , Pólipos/genética , Adolescente , Adulto , Niño , Femenino , Estudios de Seguimiento , Humanos , Masculino , Neoplasias Mandibulares/diagnóstico por imagen , Persona de Mediana Edad , Osteoma/diagnóstico por imagen , Radiografía , RiesgoAsunto(s)
Neoplasias del Colon/genética , Pólipos del Colon/genética , Neoplasias Mandibulares/diagnóstico , Neoplasias Primarias Múltiples/diagnóstico , Osteoma/diagnóstico , Neoplasias del Recto/genética , Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Primarias Múltiples/genética , RiesgoRESUMEN
Orthopantomography of the mandible was carried out on 50 patients with colorectal cancer without known familial disposition. Twelve patients (24%) had osteomas, as against 5% in the control group (P less than 0.001). Since an increased occurrence of mandibular osteomas has earlier been demonstrated in cases of familial polyposis coli and the family cancer syndrome, we must conclude that genetic factors are presumably of more importance in the development of colorectal cancer than previously assumed.
Asunto(s)
Neoplasias del Colon/genética , Neoplasias Mandibulares/genética , Neoplasias Primarias Múltiples/genética , Osteoma/genética , Neoplasias del Recto/genética , Adulto , Anciano , Femenino , Humanos , Masculino , Neoplasias Mandibulares/diagnóstico por imagen , Persona de Mediana Edad , Oncogenes , Osteoma/diagnóstico por imagen , RadiografíaAsunto(s)
Pólipos del Colon/genética , Mandíbula/diagnóstico por imagen , Neoplasias Mandibulares/diagnóstico por imagen , Osteoma/diagnóstico por imagen , Tomografía por Rayos X , Adolescente , Adulto , Anciano , Niño , Pólipos del Colon/diagnóstico por imagen , Femenino , Humanos , Masculino , Neoplasias Mandibulares/genética , Persona de Mediana Edad , Osteoma/genéticaRESUMEN
Orthopantomograms of the mandible were performed on 46 patients with familial polyposis coli having no clinical signs of Gardner's syndrome and on 46 control patients matched according to age and sex. Thirty-five patients (76.1 per cent) and two (4.3 per cent) controls had osteomas (P less than 0.0005). It is concluded that orthopantomography of the mandible is a valuable diagnostic supplement to prophylactic proctosigmoidoscopic examination of first-degree relatives of polyposis patients. Due to the frequent occurrence of mandibular osteomas in polyposis patients without clinically detectable extracolonic manifestations, it is suggested that "Gardner's syndrome" is no longer considered a clinical entity.