RESUMEN
Rat adrenals were studied using histological and histochemical methods during prolonged intoxication with pesticide magnesium chlorate which was administered in a dose equal to 1/100 of LD50 (41 mg/kg of body weight). Animals that received distilled water and were kept in similar conditions were used as control. It was demonstrated that intoxication of rats for 3-7 days results in increased secretory activity of all the zones of adrenal cortex. Later (after 14-90 days) the zonal response to pesticide administration was variable. Magnesium chlorate treatment results in the disturbances of hormonal synthesis in adrenocorticocytes. Compensatory-adaptive capacities of zona fasciculata were found to be greater than those in zona glomerulosa and zona reticularis.
Asunto(s)
Corteza Suprarrenal/efectos de los fármacos , Corteza Suprarrenal/patología , Cloratos/toxicidad , Compuestos de Magnesio/toxicidad , Administración Oral , Corteza Suprarrenal/metabolismo , Animales , Cloratos/administración & dosificación , Glucógeno/metabolismo , Inmunohistoquímica , Dosificación Letal Mediana , Metabolismo de los Lípidos , Compuestos de Magnesio/administración & dosificación , Masculino , ARN/metabolismo , Ratas , Factores de Tiempo , Zona Fascicular/efectos de los fármacos , Zona Fascicular/metabolismo , Zona Fascicular/patología , Zona Reticular/efectos de los fármacos , Zona Reticular/metabolismo , Zona Reticular/patologíaRESUMEN
Innervational connections of the heart and the superior vena cava wall have been studied in the rabbit and the man. Besides, series of their embryos, impregnated with silver salts after Cajal-Favorsky have been investigated. Methods of Bielschowsky-Gros, Gomori and Karnovsky-Roots have also been applied. Adrenergic nervous elements have been revealed by means of incubation the slices in 2% solution of glyoxylic acid. Abundant cholinergic and adrenergic nervous plexuses are revealed on the wall of the superior vena cava, they are tightly connected with corresponding plexuses of the heart. Developmental of these nervous connections is followed, when embryogenesis of the cardiac nervous plexuses and large major vessels is studied in serial sections of embryos and fetuses of the rabbit and the man.