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Resumo Movimentos ortodônticos realizados com alinhadores in-house possuem detalhes e particularidades que os diferem da mecânica ortodôntica convencional multi-bráquetes e que precisam ser respeitados pelo ortodontista na busca pela maior previsibilidade, eficácia e eficiência dos resultados. Detalhes quanto ao tipo de movimento programado para cada dente, controle de ancoragem, hierarquização das movimentações, peculiaridade da mecânica das variadas composições dos plásticos e tipos de attachments são apresentados nesta segunda parte do tutorial sobre a fabricação de alinhadores in-house (AU)

Abstract Orthodontic movements with in-house aligners entail specific details and nuances that distinguish them from traditional multi-bracket orthodontic techniques. The orthodontist must acknowledge these details to ensure greater predictability, efficacy, and efficiency in achieving desired outcomes. This second part of the in-house aligners manufacturing tutorial presents insights on tooth-specific movement requirements, anchorage control, movement hierarchy, unique aspects of plastic mechanics, and attachment types (AU)

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Resumo O uso de alinhadores para o tratamento das más oclusões tem, cada vez mais, despertado o interesse dos ortodontistas. Desde a sua apresentação no mercado, há pouco mais de duas décadas, os alinhadores vêm conquistando um importante espaço, muito em função das mudanças direcionais no exercício da especialidade, geradas pela demanda por tratamentos com uma abordagem estética e de maior conforto. Na prática, essa transformação impactou a gestão dos consultórios dos ortodontistas, habituados com o total controle sobre o fluxo de montagem e fabricação dos aparelhos convencionais. A contratação de empresas para a fabricação industrial dos alinhadores foi o conceito proposto originalmente pela Align Technology, fabricante do Invisalign, pioneira nesse sistema comercial e líder no mercado. Entretanto, em função dos custos inerentes a esse serviço, bem como das limitações temporais impostas pela terceirização, foi criado um fluxo digital de fabricação in-house dos alinhadores, pelos próprios ortodontistas. Diante dessa realidade, o objetivo desta série de três artigos é trazer, aos ortodontistas iniciantes na técnica, considerações práticas para o início do emprego na fabricação própria de alinhadores. Adicionalmente, objetiva-se compartilhar, com os profissionais que já são usuários desse tipo de sistema, experiências relacionadas à fabricação e à gestão da técnica. (AU)

Abstract Clear aligner treatment has gained interest among orthodontists since its introduction in the market two decades ago. The high patients' demand for more aesthetic approaches, with greater comfort, is the primary aspect driving this direction change in the treatment of the malocclusions. However, this drift impacted the management of clinical practices because orthodontists lost absolute control over the flow of assembly and manufacture of conventional appliances. Third-party companies hired for the industrial manufacture of aligners was the concept initially proposed by Align Technology, manufacturer of Invisalign, a pioneer in the commercial system and market leader. Nevertheless, due to the inherent costs of this service and the time limitations imposed by outsourcing, the orthodontists created a digital flow for in-house manufacturing of aligners. This series of three articles brings practical considerations for using in-office aligners. Additionally, the goal is to share experiences related to the manufacture and management of the technique (AU)

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Resumo Após o planejamento virtual dos movimentos ortodônticos em plataformas apropriadas e a exportação dos diversos modelos digitais de subsetups, inicia-se a fase laboratorial de fabricação dos alinhadores in house, com a impressão 3D de modelos em resina fotossensível, seguida dos processos de lavagem e pós-cura. Assim, os modelos estarão prontos para serem estampados com variadas opções de laminados poliméricos termoplastificados, que serão recortados, receberão acabamento fino, higienizados e entregues aos pacientes. Na terceira parte do tutorial, serão apresentados esses conceitos práticos da fabricação de alinhadores in house. (AU)

Abstract Following the virtual planning of orthodontic movements using suitable platforms and the resulting exportation of multiple digital models of sub-setups, the laboratory phase begins to produce in house aligners. This phase involves the utilization of 3D printing technology to fabricate models using photosensitive resin, followed by additional steps of washing and post-curing. The models are then prepared for printing using a range of thermoplastic polymer laminate choices. After this, they are meticulously trimmed, refined, sterilized, and subsequently, disseminated to the intended recipients. The current part 3 of the tutorial will focus on the practical concepts involved in the in house production of aligners(AU)

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OBJECTIVE: To develop and make available, at no cost to the user, Information and Communications Technology (ICT) tools for Dentistry, providing dental information and advice geared toward patients undergoing orthodontic treatment with fixed appliances. MATERIAL AND METHODS: A Dentistry-based content that contemplated information and advice concerning orthodontic treatment with fixed appliances was elaborated. The materials, which included instructions on oral hygiene and treatment strategies when faced with possible complications, were evaluated and validated by specialists, whose assessments reached a 85% approval. From the validated content, products using four distinct ICT tools were formulated. RESULTS: The following technological products were developed: a program for community radios, three blog posts, four educational and informative videos, and a smartphone application - using texts, as well as images and videos. These ICT tools, geared toward patients wearing fixed orthodontic appliances, were made available by internet at no cost to the user, and the number of accesses is already expressive. CONCLUSION: These technological-scientific tools, developed and provided freely to the population, can aid patients during their treatment with fixed orthodontic appliances, contributing to the dissemination of reliable information, and clarifying doubts that may arise during orthodontic therapy. These free ICT tools serve to facilitate access to scientific knowledge, thereby favoring social inclusion, bearing in mind that this educational and informative material was offered in a simple and accessible manner to the general population.

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ABSTRACT Objective: To develop and make available, at no cost to the user, Information and Communications Technology (ICT) tools for Dentistry, providing dental information and advice geared toward patients undergoing orthodontic treatment with fixed appliances. Material and Methods: A Dentistry-based content that contemplated information and advice concerning orthodontic treatment with fixed appliances was elaborated. The materials, which included instructions on oral hygiene and treatment strategies when faced with possible complications, were evaluated and validated by specialists, whose assessments reached a 85% approval. From the validated content, products using four distinct ICT tools were formulated. Results: The following technological products were developed: a program for community radios, three blog posts, four educational and informative videos, and a smartphone application - using texts, as well as images and videos. These ICT tools, geared toward patients wearing fixed orthodontic appliances, were made available by internet at no cost to the user, and the number of accesses is already expressive. Conclusion: These technological-scientific tools, developed and provided freely to the population, can aid patients during their treatment with fixed orthodontic appliances, contributing to the dissemination of reliable information, and clarifying doubts that may arise during orthodontic therapy. These free ICT tools serve to facilitate access to scientific knowledge, thereby favoring social inclusion, bearing in mind that this educational and informative material was offered in a simple and accessible manner to the general population.

RESUMO Objetivos: Desenvolver e disponibilizar, gratuitamente, ferramentas de tecnologia da informação e comunicação (TIC) para a Odontologia, abordando informações e orientações direcionadas a pacientes em tratamento ortodôntico com aparelho fixo. Material e Métodos: Foi elaborado um conteúdo que contemplou informações e orientações concernentes ao tratamento ortodôntico com aparelho fixo. O material, que abrangeu instruções sobre higiene bucal e sobre abordagens diante de possíveis intercorrências, foi avaliado e validado por especialistas. A partir do conteúdo validado, foram elaborados produtos utilizando quatro ferramentas distintas de TIC. Resultados: Foram desenvolvidos os seguintes produtos tecnológicos: um programa para rádios comunitárias, três postagens para blog, quatro vídeos educacionais e informativos, e um aplicativo para smartphones, utilizando não apenas textos, mas também imagens e vídeos. Essas ferramentas de TIC direcionadas a pacientes fazendo uso de aparelho ortodôntico fixo foram disponibilizadas gratuitamente via internet, e já contam com expressivo número de acessos. Conclusões: As ferramentas técnico-científicas, desenvolvidas e fornecidas livremente à população, podem auxiliar pacientes durante o tratamento com aparelho ortodôntico fixo, contribuir para disseminar informações confiáveis e esclarecer dúvidas que surgem durante a terapia ortodôntica. Essas ferramentas gratuitas de TIC facilitam o acesso ao conhecimento científico e, consequentemente, favorecem a inserção social, tendo em vista que esse material educacional e informativo foi ofertado de maneira simples e acessível à população.

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PURPOSE: To investigate whether there is any effect resulting from preconditioning with nutraceutical supplementation containing arginine and oil mixes with high ω9:ω6 ratio and low ω6:ω3 ratio containing EPA and DHA, ALA fatty acids on inflammatory mediators, antioxidant and lipid profile modulation in surgical trauma. METHODS: Twenty-six men scheduled for radical prostatectomy were randomized into three groups and treated as follows: Group 1 (skim milk, 0% fat), Group 2 (supplement with ω6:ω3 ratio of 8:1 and arginine) and Group 3 (supplement with high ω9:ω6 ratio of 3.2:1 and low ω6:ω3 ratio of 1.4:1 and arginine). Patients received skin milk or supplements twice a day (200 ml) during five days prior to surgery. Peripheral venous blood samples were collected at three different timepoints: five days before surgery (PRE), before anesthesia induction (IND) and on the 2nd postoperative day (POS). Parameters analyzed included inflammatory cytokines (IL-1ß, IL-6, IL-8 and TNF-α), antioxidants (catalase), lipid profile and heat shock protein (HSP-27). RESULTS: There were no significant differences between groups on inflammatory mediators and antioxidant parameters. However, lipid profile values (Cholesterol, LDL, Triglycerides, VLDL), were significantly different. CONCLUSION: Preconditioning with arginine and oil mixes containing high ω9:ω6 ratio and low ω6:ω3 ratio, has no effects on inflammatory mediators and oxidative stress in patients undergoing radical prostatectomy. Reduction of cholesterol, triglycerides, LDL and VLDL profiles may be related to the trauma effect.

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PURPOSE: To investigate whether there is any effect resulting from preconditioning with nutraceutical supplementation containing arginine and oil mixes with high ω9:ω6 ratio and low ω6:ω3 ratio containing EPA and DHA, ALA fatty acids on inflammatory mediators, antioxidant and lipid profile modulation in surgical trauma. METHODS: Twenty-six men scheduled for radical prostatectomy were randomized into three groups and treated as follows: Group 1 (skim milk, 0% fat), Group 2 (supplement with ω6:ω3 ratio of 8:1 and arginine) and Group 3 (supplement with high ω9:ω6 ratio of 3.2:1 and low ω6:ω3 ratio of 1.4:1 and arginine). Patients received skin milk or supplements twice a day (200 ml) during five days prior to surgery. Peripheral venous blood samples were collected at three different timepoints: five days before surgery (PRE), before anesthesia induction (IND) and on the 2nd postoperative day (POS). Parameters analyzed included inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α), antioxidants (catalase), lipid profile and heat shock protein (HSP-27). RESULTS: There were no significant differences between groups on inflammatory mediators and antioxidant parameters. However, lipid profile values (Cholesterol, LDL, Triglycerides, VLDL), were significantly different. CONCLUSION: Preconditioning with arginine and oil mixes containing high ω9:ω6 ratio and low ω6:ω3 ratio, has no effects on inflammatory mediators and oxidative stress in patients undergoing radical prostatectomy. Reduction of cholesterol, triglycerides, LDL and VLDL profiles may be related to the trauma effect. .

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The present work was carried out to evaluate the in vitro development of bovine embryo co-cultured in granulosa, oviduct, BRL or VERO cells co-cultures, supplemented with 5% or 10% of Fetal Calf Serum (FCS). Cummulus oocyte complexes were aspirated, matured and fertilized in vitro. Embryonic structures were divided into eight treatments. They were placed in culture media TCM 199 containing granulosa, oviduct, BRL or VERO cells, each of them added with 5% or 10% FCS. The conditions for the co-culture were 38.5 ºC, 5% CO2 in air and high humidity for ten consecutive days. Cleavage, blastocyst and hatching rates did not differ (p > 0.05) in co-culture with primary cells (granulosa and oviduct) when FCS concentration increased from 5 to 10%. However, in continuous cells co-culture (BRL and VERO), when FCS concentration increased from 5% to 10%, the blastocyst development rate decreased significantly (p < 0.05) from 33.6 to 16.3% and from 40 to 16.5% in embryo co-culture with BRL and VERO cells, respectively.

O presente trabalho foi realizado com o objetivo de avaliar o desenvolvimento in vitro de embriões bovinos co-cultivados em células da granulosa, do oviduto, BRL e VERO, suplementados com 5% ou 10% de Soro Fetal Bovino (SFB). Os complexos cummulus oócitos foram aspirados, maturados e fecundados in vitro. As estruturas embrionárias foram divididas em oito tratamentos: co-cultivo em TCM 199 contendo células da granulosa, do oviduto, BRL ou VERO adicionadas com 5% ou 10% de SFB. As condições de cultivo foram 38.5 ºC, 5% CO2 em ar e alta humidade por dez dias consecutivos. Os índices de clivagem, blastocisto e eclosão não diferiram (p > 0,05) no co-cultivo com células primárias (granulosa e oviduto) quando a concentração de SFB aumentou de 5 para 10%. Entretanto, no co-cultivo com células de linhagens contínuas (BRL e VERO), quando a concentração de SFB aumentou de 5% para 10%, os índices de blastocistos diminuíram significativamente (p < 0,05) de 33,6 para 16,3 % e de 40 para 16,5% nos embriões bovinos co-cultivados com células VERO e BRL, respectivamente.

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