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Background: Surgical repair of full-thickness rotator cuff tears in symptomatic patients is known to offer significant benefits. Despite this there remains a lack of universal appreciation that such surgery offers high clinical value, with some commissioners even limiting access to it. The value-based healthcare agenda provides a means to design, deliver and measure the impact of healthcare to a defined segment of patients. The aim of this study was to measure the value of surgically repairing primary symptomatic full-thickness rotator cuff tears when outcomes and costs were assessed over an entire care pathway. Methods: A prospective study of patients undergoing rotator cuff tears repair was undertaken. Patients were managed using a standardised integrated care pathway. Subsequent outcomes and costs were measured over the whole care pathway. Outcomes were assessed from both traditional and patient centric re-formatted prisms. Results: Significant improvement in clinical outcomes where recognised when assessed from either the traditional or re-formatted prisms. Economic review of this approach revealed the pathway generated a sustainable and notable positive margin. Discussion: This study evidences how a well-designed value-based healthcare shoulder approach can be delivered and measured. It demonstrates rotator cuff surgery to be a high value treatment for patients with symptomatic rotator cuff tears.
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Background: Shoulder arthroplasty surgery carries the risk of blood loss. The antifibrinolytic tranexamic acid (TXA) is effective in reducing blood loss in lower limb arthroplasty. The purpose of this study was to assess blood loss and associated complications following shoulder arthroplasty performed with and without TXA for both elective and trauma indications. Methods: A cohort study was performed to assess blood loss, transfusion requirements and post-operative venous thromboembolic events (VTE) following shoulder arthroplasty undertaken with and without the use of intravenous TXA. Results: The study consisted of 67 patients (n = 36 with TXA; n = 31 without TXA). Type of arthroplasty included reverse-shoulder arthroplasty, total-shoulder arthroplasty and hemiarthroplasty. There was no significant difference between TXA and non-TXA groups regarding blood loss (TXA group haemoglobin drop 20.6 mg/dL; non-TXA group haemoglobin drop 20.5 mg/dL; p = 0.978). There was no significant difference in measured outcomes with or without TXA use for elective or trauma indications, nor regarding type of arthroplasty. Discussion: The use of intravenous TXA in shoulder arthroplasty was not associated with a significant reduction in blood loss or post-operative transfusion rates, nor did it impact on VTE. This result was not affected by the indication being elective or trauma nor the type of arthroplasty surgery performed.
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BACKGROUND: Lateral end clavicle fractures can be challenging due to the small and often comminuted lateral fragment, problems with union and stability and implant morbidity. We retrospectively reviewed outcomes of Tightrope device in isolation to treat lateral end clavicle fractures. METHODS: Subjective and objective measures were assessed for 29 patients. The subjective comprised of functional clinical scores: Oxford shoulder score and EuroQoL5D. The objective measures were maintenance of fracture reduction, bone healing and complications. RESULTS: Median age was 36 years and 72% of cases were male patients. Average clinical follow up time was 21 months. Evaluation of latest radiographs showed that all reductions were maintained post-operatively. Twenty-two fractures had united and one patient had established non-union. Functional outcomes showed predominantly good results with Oxford shoulder score average of 41, EuroQoL5D index score of 0.78 and EuroQol Visual Analogue Scale 76. The overall post-operative complication rate was 10%; only one case requiring a secondary procedure. DISCUSSION: In our series, using the Tightrope as the sole device to treat displaced lateral end of clavicle fractures resulted in good radiological and functional outcomes, with minimal complications requiring secondary procedures. We believe the Tightrope device is a good method of fixing these challenging fractures and advocate its use.
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The use of robots in orthopaedic surgery is an emerging field that is gaining momentum. It has the potential for significant improvements in surgical planning, accuracy of component implantation and patient safety. Advocates of robot-assisted systems describe better patient outcomes through improved pre-operative planning and enhanced execution of surgery. However, costs, limited availability, a lack of evidence regarding the efficiency and safety of such systems and an absence of long-term high-impact studies have restricted the widespread implementation of these systems. We have reviewed the literature on the efficacy, safety and current understanding of the use of robotics in orthopaedics.
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Procedimientos Ortopédicos/instrumentación , Robótica , Cirugía Asistida por Computador/instrumentación , Heridas y Lesiones/cirugía , Artroplastia de Reemplazo , Diagnóstico por Imagen , HumanosRESUMEN
We describe a case of medial clavicular physeal separation with posterior displacement of the metaphysis in a 13-year-old girl, focusing on the role played by ultrasound in the diagnosis, planning of treatment and post-reduction follow-up. On clinical examination and conventional radiography, the injury is essentially indistinguishable from a sternoclavicular dislocation or a fracture of the medial aspect of the clavicle; however, the pathogenesis is different, consisting in medial physeal separation and 'degloving' of the inner cancellous bone of the metaphysis from the surrounding periosteal collar with posterior metaphyseal dislocation. In our case, attempted closed reduction failed, and the injury required open reduction with relocation of the clavicle into the periosteal sleeve followed by suturing of the periosteal tear.
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BACKGROUND: We previously demonstrated vagal neural pathways, specifically subdiaphragmatic afferent fibers, regulate expression of the intestinal sodium-glucose cotransporter SGLT1, the intestinal transporter responsible for absorption of dietary glucose. We hypothesized targeting this pathway could be a novel therapy for obesity. We therefore tested the impact of disrupting vagal signaling by total vagotomy or selective vagal de-afferentation on weight gain and fat content in diet-induced obese rats. METHODS: Male Sprague-Dawley rats (n = 5-8) underwent truncal vagotomy, selective vagal de-afferentation with capsaicin, or sham procedure. Animals were maintained for 11 months on a high-caloric Western diet. Abdominal visceral fat content was assessed by magnetic resonance imaging together with weight of fat pads at harvest. Glucose homeostasis was assessed by fasting blood glucose and HbA1C. Jejunal SGLT1 gene expression was assessed by qPCR and immunoblotting and function by glucose uptake in everted jejunal sleeves. RESULTS: At 11-months, vagotomized rats weighed 19% less (P = 0.003) and de-afferented rats 7% less (P = 0.19) than shams. Vagotomized and de-afferented animals had 52% (P < 0.0001) and 18% reduction (P = 0.039) in visceral abdominal fat, respectively. There were no changes in blood glucose or glycemic indexes. SGLT1 mRNA, protein and function were unchanged across all cohorts at 11-months postoperatively. CONCLUSIONS: Truncal vagotomy led to significant reductions in both diet-induced weight gain and visceral abdominal fat deposition. Vagal de-afferentation led to a more modest, but clinically and statistically significant, reduction in visceral abdominal fat. As increased visceral abdominal fat is associated with excess morbidity and mortality, vagal de-afferentation may be a useful adjunct in bariatric surgery.
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Vías Aferentes , Capsaicina/uso terapéutico , Glucosa , Obesidad , Células Receptoras Sensoriales/efectos de los fármacos , Vagotomía/métodos , Vías Aferentes/efectos de los fármacos , Vías Aferentes/cirugía , Animales , Peso Corporal , Diafragma/inervación , Diafragma/fisiopatología , Dieta/efectos adversos , Modelos Animales de Enfermedad , Glucosa/análisis , Glucosa/metabolismo , Absorción Intestinal , Grasa Intraabdominal/efectos de los fármacos , Yeyuno/metabolismo , Masculino , Obesidad/etiología , Obesidad/metabolismo , Obesidad/fisiopatología , Obesidad/terapia , Ratas , Ratas Sprague-Dawley , Fármacos del Sistema Sensorial/uso terapéutico , Transportador 1 de Sodio-Glucosa/metabolismo , Resultado del Tratamiento , Nervio Vago/cirugíaRESUMEN
BACKGROUND: Day surgery trauma lists are becoming an increasingly popular and widespread approach to address the inpatient trauma demand on NHS services. A 'Rapid Access' list initiative was set-up to book patients from an emergency pathway who require surgery and also fulfilled the standard day case patient criteria but for whom it was safe to wait for over 24 h before going to theatre. MATERIALS & METHODS: We performed a prospective audit of the cases undertaken on the day surgery trauma list over a 12-month period and analysed the number of cases, spectrum of procedures, complications and the cost benefits. RESULTS: A total of 119 day surgery trauma cases were performed (42 lists; average of 3 cases per list; upper limb procedures accounted for 60%.). The overall cost benefit for day surgery was calculated as the difference between the tariff and the costs for day surgery and inpatient procedures. A cost benefit of £617 per case for day surgery over inpatient surgery was noted with a total saving of £67,450 for the performed procedures. DISCUSSION: We demonstrate day trauma surgery to be a safe and cost effective method of optimising the management of the appropriate trauma case workload. Further it reduces demand for inpatient beds, provides significant cost savings for the trust and improves patient satisfaction.
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Procedimientos Quirúrgicos Ambulatorios/economía , Procedimientos Quirúrgicos Ambulatorios/estadística & datos numéricos , Heridas y Lesiones/epidemiología , Adolescente , Adulto , Anciano , Niño , Preescolar , Análisis Costo-Beneficio , Costos y Análisis de Costo , Femenino , Humanos , Masculino , Auditoría Médica , Persona de Mediana Edad , Estudios Prospectivos , Reino Unido , Carga de Trabajo/economía , Carga de Trabajo/estadística & datos numéricos , Heridas y Lesiones/economía , Heridas y Lesiones/cirugía , Adulto JovenRESUMEN
To investigate the relationship between age, gender and the Constant score. Two hundred and seventy Healthy volunteers (527 normal shoulders) from our local population with no previous history of shoulder disease were assessed using the Constant score. The mean age was 43.9 years (16-86) and the mean Constant score 85.9 (56-100). The mean score was 88.1 (range 56-100) for men and 83.7 (range 60-100) for women. A mixed regression model estimated that, for the male population, the Constant score falls by 0.15 points per annum between the ages of 50 and 70 and by 1.3 points per year after the age of 70. Similarly, for the female population, the fall is of 0.25 per year between 60 and 70 and 0.35 after the age of 70. The changes are statistically significant (P < 0.01) and clinically important when comparing patients of different age groups.
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Indicadores de Salud , Rango del Movimiento Articular , Articulación del Hombro/fisiología , Dolor de Hombro/epidemiología , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia , Factores Sexuales , Población Urbana/estadística & datos numéricos , Adulto JovenRESUMEN
The purpose is to perform a comparative analysis of mini-open and arthroscopic rotator cuff repairs through the use of subjective and objective scoring tools. We conducted a prospective comparative cohort study that evaluated 123 consecutive patients who underwent rotator cuff repairs (arthroscopic and 31 mini-open repair). Subjective and objective functional assessment was performed preoperatively and postoperatively at 3, 6, 12, 18 and 24 months using the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, the Oxford Shoulder Score (OSS) and the Constant-Murley score. Statistical analysis was performed on the datasets assessing the Pearson correlation coefficients and any significant differences present at each respective time point. At every time point the arthroscopic group scored better than the mini-open group, regardless of the assessment tool employed. The percentage recovery from the baseline measured at 1 year was similar with either treatment option. A significant difference was found between the arthroscopic and mini-open groups for the Constant-Murley, DASH and OSS scoring systems preoperatively (P < 0.05), reflecting a difference in tear severity. Arthroscopic rotator cuff repair is comparable with the mini-open technique with well correlated postoperative rates recovery. Subjective scoring provides an accurate and potentially easier method of postoperative assessment for long-term follow-up of rotator cuff repairs.
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Artroscopía/métodos , Procedimientos Ortopédicos/métodos , Recuperación de la Función , Manguito de los Rotadores/cirugía , Evaluación de la Discapacidad , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Lesiones del Manguito de los RotadoresRESUMEN
Between 1986 and 1991 we implanted 331 consecutive Furlong hydroxyapatite-coated femoral components of a total hip replacement in 291 patients. A cemented acetabular prosthesis was used in 217 hips and a hydroxyapatite-coated component in 114. We describe the long-term clinical and radiological survival of the femoral component at a mean follow-up of 17.5 years (15 to 21). Only two patients (0.68%) were lost to follow-up. With revision of the femoral component for any reason as the endpoint, the survival at a mean of 17 years was 97.4% (95% confidence interval 94.1 to 99.5), and with revision for aseptic loosening as the endpoint it was 100%. The survival at a maximum of 21 years with revision of the femoral component for any reason as the endpoint was 97.4% (95% confidence interval 81.0 or 99.5). These results compare favourably with the best long-term results of cemented or uncemented femoral components used in total hip replacement.
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Acetábulo/cirugía , Artroplastia de Reemplazo de Cadera/métodos , Materiales Biocompatibles/uso terapéutico , Durapatita/uso terapéutico , Articulación de la Cadera/cirugía , Prótesis de Cadera , Adulto , Anciano , Anciano de 80 o más Años , Cementación , Inglaterra , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Estudios Prospectivos , Diseño de Prótesis , Falla de Prótesis , Resultado del TratamientoRESUMEN
We report on a 67-year-old lady with multiple sclerosis (MS) who underwent bilateral total knee replacements using a fixed bearing posterior cruciate retaining prosthesis. Having initially achieved a satisfactory result, she developed recurrent dislocations of both knees necessitating bilateral revision surgery. Such complications are not previously described as a sequela of a neurological disease.
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Artroplastia de Reemplazo de Rodilla/efectos adversos , Luxación de la Rodilla/complicaciones , Esclerosis Múltiple/complicaciones , Falla de Prótesis , Anciano , Femenino , Humanos , Luxación de la Rodilla/cirugía , Osteoartritis de la Rodilla/cirugía , ReoperaciónRESUMEN
BACKGROUND AND STUDY AIMS: A natural orifice transluminal endoscopic surgery (NOTES) approach to ventral wall hernia repair may represent a potentially less invasive alternative to current transabdominal surgical techniques. We aimed to investigate the feasibility of using transcolonic NOTES to deliver hernia repair mesh into the peritoneal cavity, as well as the ability to manipulate composite mesh and secure it to the abdominal wall. METHODS: Five pigs weighing 20 to 25 kg were used in this feasibility study involving two acute and three survival experiments. A prototype mesh delivery system was used to transfer 1.5 - 2-cm x 2.5 - 3-cm pieces of composite hernia mesh into the peritoneal cavity. Neodymium magnets on a prototype control arm were used to help position the mesh by magnetically engaging previously placed endoscopic clips. Transfascial fixation of the mesh with 3-0 monofilament sutures was achieved using a 19-gauge hollow needle, pusher wire, and a suture tag system. RESULTS: Composite hernia mesh was successfully transferred and secured in 5/5 attempts. All three survival animals thrived for 14 days prior to elective sacrifice. At necropsy, the mesh sites were found to be well peritonealized without adhesions. Suture placement through the posterior fascia was confirmed in 10/12 sutures. Of these, four sutures were within the abdominal musculature, and two sutures were through the anterior fascia (transfascial). CONCLUSIONS: Transcolonic delivery, transcutaneous magnetic manipulation, and fixation of composite hernia mesh are technically feasible in a porcine model with animal survival. An effective suturing method that allows consistent anchoring through the anterior fascia would be preferred and may require the development of novel devices.
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Colonoscopios , Colonoscopía/métodos , Hernia Ventral/cirugía , Implantación de Prótesis/instrumentación , Mallas Quirúrgicas , Técnicas de Sutura/instrumentación , Animales , Colon , Modelos Animales de Enfermedad , Diseño de Equipo , Femenino , Estudios de Seguimiento , Porcinos , Resultado del TratamientoRESUMEN
BACKGROUND AND STUDY AIMS: Natural orifice transluminal endoscopic surgery (NOTES) is a potentially less invasive alternative to laparoscopic surgery that may be applicable to distal pancreatectomy. We aimed to demonstrate the technical feasibility of a NOTES distal pancreatectomy in an in vivo porcine model via a combined transvaginal-transcolonic approach. MATERIAL AND METHODS: The procedure was performed in five female Yorkshire pigs weighing approximately 30 kg each. A prototype endoscope ("R-scope"), advanced into the peritoneal cavity through an anterior colotomy, and a computer-assisted linear stapler, introduced transvaginally, were used in dissection and resection of the distal pancreas. Prone positioning was used to enhance retroperitoneal exposure. Pneumodissection was used for blunt dissection. The colotomies were closed with endoloops. Necropsies were done immediately after the procedure in the first three animals, and after 2 weeks' survival in the final two animals. RESULTS: Distal pancreatectomy was successful in all five animals. Prone positioning was critically important for proper exposure of retroperitoneal and pelvic structures. Pneumodissection was effective for blunt dissection, and both the linear stapler and R-scope functioned smoothly. Transvaginal and transcolonic access provided similar intraperitoneal views, and the dual-lumen approach enhanced triangulation. Both survival animals thrived postoperatively. Necropsies revealed clean staple lines; closed transcolonic and transvaginal incisions; and absence of infection, hemorrhage, or fluid collections. CONCLUSIONS: NOTES distal pancreatectomy is technically feasible in the porcine model. The transvaginal approach provides a vantage point very similar to that of the transcolonic route and holds promise as a NOTES access site, either singly or as part of a dual-lumen approach. The endoscopic linear stapler and R-scope both advance NOTES capabilities. The novel concepts of fully prone positioning, pneumodissection, and endoloop colotomy closures are introduced. Considering anatomical differences and that healthy animals were used, transferring this technique to patients with pancreatic disease might be difficult and further modifications would likely be needed.
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Endoscopios , Endoscopía del Sistema Digestivo/métodos , Pancreatectomía/instrumentación , Enfermedades Pancreáticas/cirugía , Engrapadoras Quirúrgicas , Técnicas de Sutura/instrumentación , Animales , Colon , Modelos Animales de Enfermedad , Endoscopía del Sistema Digestivo/mortalidad , Diseño de Equipo , Estudios de Factibilidad , Femenino , Estudios de Seguimiento , Pancreatectomía/mortalidad , Tasa de Supervivencia , Porcinos , Resultado del Tratamiento , VaginaRESUMEN
This case report describes a fracture of the neck of a femoral component of a Furlong (JRI Limited, London) hydroxyapatite-coated cementless total hip arthroplasty.
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Fémur , Prótesis de Cadera , Artroplastia de Reemplazo de Cadera , Materiales Biocompatibles Revestidos , Durapatita , Humanos , Masculino , Persona de Mediana Edad , Falla de PrótesisAsunto(s)
Mamoplastia , Complicaciones Posoperatorias/diagnóstico , Piodermia Gangrenosa/diagnóstico , Mama/patología , Ciclosporina/uso terapéutico , Diagnóstico Diferencial , Femenino , Gangrena/diagnóstico , Humanos , Inmunosupresores/uso terapéutico , Persona de Mediana Edad , Complicaciones Posoperatorias/tratamiento farmacológico , Piodermia Gangrenosa/tratamiento farmacológicoRESUMEN
Closed, high-energy transfer traction injuries of the adult brachial plexus lead to rupture or avulsion of the spinal nerves. Accurate preoperative diagnosis is crucial for surgical planning and reconstruction. Myelography, computerised tomographic myelography and magnetic resonance imaging are the main radiological methods for preoperative diagnosis of the lesion. This article reviews the current status of imaging of traction injuries of the adult brachial plexus.
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Neuropatías del Plexo Braquial/diagnóstico , Plexo Braquial/lesiones , Diagnóstico por Imagen , Heridas no Penetrantes/diagnóstico , Adulto , Plexo Braquial/patología , Plexo Braquial/cirugía , Neuropatías del Plexo Braquial/patología , Humanos , Raíces Nerviosas Espinales/lesiones , Raíces Nerviosas Espinales/patología , Raíces Nerviosas Espinales/cirugía , TracciónRESUMEN
Lymphatic malformations are a type of vascular anomaly. They are uncommon and can present in various ways. Associated hypertrophy of the soft tissue and bone have been described in association with deep lymphatic connections, but late-onset localised fat hypertrophy in the absence of deep connections has not been previously described. We present a case of cutaneous lymphatic malformation of the thigh and buttock with secondary fat hypertrophy. The lesion had been present since childhood but enlarged rapidly during adolescence. MRI excluded deep connections and lipoma. Liposuction was used to debulk the area with a satisfactory result.
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Tejido Adiposo/patología , Sistema Linfático/anomalías , Adulto , Femenino , Humanos , Hipertrofia/diagnóstico , Hipertrofia/etiología , Hipertrofia/cirugía , Pierna , Lipectomía/métodos , Imagen por Resonancia Magnética/métodos , Resultado del TratamientoRESUMEN
BACKGROUND: Growth hormone (GH) has been used alone or as part of a defined regimen in the treatment of patients with short bowel syndrome; however its mode of action remains unclear. Growth hormone has been shown to increase amino acid, water, and electrolyte absorption from the small intestine. The acute effect of growth hormone on intestinal sugar transport has not been described previously. METHODS: Mucosal preparations of rat jejunum were mounted in the Ussing chamber. Growth hormone (2 x 10(-6) M or 8 x 10(-6) M) or vehicle was added to the serosal chamber 1, 3, or 5 hours later. Twenty or 40 minutes after growth hormone addition, 30 mmol/L 3-O-methylglucose was added to both chambers, and the change in short-circuit current (deltaIsc) was recorded. In separate experiments, tissues were pretreated with phloridzin, an inhibitor of Na+/glucose cotransport, before the addition of 3-O-methylglucose. In the final set of experiments, kinetic studies were performed. RESULTS: GH did not induce any alterations in baseline electrical parameters. Only tissues left in the chambers for 5 hours, but not 1 or 3 hours, before GH treatment displayed a greater 3-O-methylglucose-induced deltaIsc than controls (p < .05). The increase in Isc induced by 3-O-methylglucose was 100% phloridzin-inhibitable. Kinetic analysis showed that growth hormone administration is associated with an increase in Na+/glucose cotransporter maximal velocity (Vmax) but no significant change in carrier affinity for substrate (Km). CONCLUSIONS: Growth hormone increases intestinal sugar transport, but only in tissue that has not been exposed to endogenous GH for over 3 hours.
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Hormona del Crecimiento/farmacología , Yeyuno/metabolismo , Proteínas de Transporte de Monosacáridos/efectos de los fármacos , Síndrome del Intestino Corto/tratamiento farmacológico , 3-O-Metilglucosa/farmacocinética , Animales , Transporte Biológico/efectos de los fármacos , Hormona del Crecimiento/uso terapéutico , Técnicas In Vitro , Yeyuno/efectos de los fármacos , Masculino , Proteínas de Transporte de Monosacáridos/antagonistas & inhibidores , Florizina/farmacología , Ratas , Ratas Sprague-Dawley , Factores de TiempoRESUMEN
Mechanisms underlying the circadian rhythmicity in intestinal sugar absorption remain unclear. To test whether this rhythmicity is caused by changes in Na(+)-glucose cotransporter 1 (SGLT-1) function, we measured phloridzin-inhibitable sugar fluxes as an index of SGLT-1 activity. Jejunum obtained from rats killed at 6-h intervals during a 12-h light-dark cycle (CT0 is circadian time 0 h, time of light onset) were mounted in Ussing chambers, and 3-O-methylglucose (3-OMG) fluxes were calculated before and after addition of phloridzin. 3-OMG-induced change in short-circuit current and absorptive flux were significantly greater at CT9 than at CT3. This increase was phloridzin inhibitable. Kinetic studies indicated a significant increase in SGLT-1 maximal velocity (V(max)) at CT9. Food intake between CT3 and CT9 was <10% of the daily total, indicating that the increased SGLT-1 activity was anticipatory. Diurnicity of SGLT-1 mRNA was confirmed by Northern blotting. Expression topography analyzed by in situ hybridization revealed more intense labeling along the entire villus axis at CT9 and CT15 compared with CT3 and CT21. We conclude that diurnicity in intestinal sugar absorption is caused by periodicity in SGLT-1 V(max).