RESUMEN

Special agents for protein capture: Iterative in situ click chemistry (see scheme for the tertiary ligand screen) and the one-bead-one-compound method for the creation of a peptide library enable the fragment-based assembly of selective high-affinity protein-capture agents. The resulting ligands are water-soluble and stable chemically, biochemically, and thermally. They can be produced in gram quantities through copper(I)-catalyzed cycloaddition.

Asunto(s)

Biblioteca de Péptidos , Proteínas/química , Triazoles/química , Anticuerpos/química , Catálisis , Cobre/química , Ligandos , Péptidos/química , Unión Proteica