RESUMEN
PURPOSE/OBJECTIVES: To analyze the clinical features, treatment modalities and outcome of patients treated for a localized esthesioneuroblastoma (ENB). MATERIALS AND METHODS: Forty-three consecutive patients with biopsy proven ENB treated at two referral cancer centers between 1998 and 2010 were retrospectively reviewed. RESULTS: Overall, 5 patients had stage A disease, 13 stage B, 16 stage C and 9 stage D according to the modified Kadish classification. Neo-adjuvant chemotherapy was performed in 23 patients leading to a 74 % response rate. Thirty-one patients were treated by surgery. Thirty-nine patients (90.6%) underwent radiation therapy. Twelve patients received bilateral cervical lymph node irradiation (LNI). After a median follow-up of 77 months, the 5-year overall and progression free survival were 65% and 57%. Twelve patients (28%) had a locoregional relapse leading to 10 ENB-related deaths. The major prognostic factor was the modified Kadish stage with a 3-year survival for stage A-B, C and D of 100%, 48% and 22% respectively (p < 0.0001). Two (9%) isolated cervical lymph node relapses occurred among staged B and C patients treated without elective LNI and none after elective or adjuvant LNI. CONCLUSION: The high risk of locoregional failure in ENB justifies the use of multimodal therapy. Induction chemotherapy leads to a high response rate. Elective LNI might prevent regional failure in locally advanced disease.
Asunto(s)
Estesioneuroblastoma Olfatorio/terapia , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Estesioneuroblastoma Olfatorio/diagnóstico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis de Supervivencia , Resultado del Tratamiento , Adulto JovenRESUMEN
Acute radiation dermatitis remains one of the most commonly observed side effect during radiation therapy leading to complication such as superinfection or treatment disruption. Its management is characterized by a great heterogeneity. Few strategies have demonstrated a benefit in preventing radiation dermatitis, which relies mostly on decreasing dose delivered to the skin and skin care practices. Simple emollients and use of topical steroids can be useful in early stages. The singularity of the skin toxicity seen with cetuximab and radiotherapy warrants a specific grading system and distinctive clinical treatment with use of antibiotics.
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Radiodermatitis/terapia , Adyuvantes Inmunológicos/uso terapéutico , Analgésicos/uso terapéutico , Antiinfecciosos Locales/uso terapéutico , Anticuerpos Monoclonales/efectos adversos , Anticuerpos Monoclonales Humanizados , Antineoplásicos/efectos adversos , Vendas Hidrocoloidales , Calendula , Cetuximab , Fármacos Dermatológicos/uso terapéutico , Eosina Amarillenta-(YS)/uso terapéutico , Etanolaminas/uso terapéutico , Glucocorticoides/uso terapéutico , Humanos , Ácido Hialurónico/uso terapéutico , Metilprednisolona/uso terapéutico , Fitoterapia , Radiodermatitis/clasificación , Radioterapia/efectos adversos , Dosificación Radioterapéutica , Índice de Severidad de la Enfermedad , Cuidados de la PielRESUMEN
EGFR is frequently overexpressed and is associated with a poor prognosis in head and neck carcinoma (HNC). Among the biological and cellular effects resulting from EGFR targeting, there are the possibilities to restore apoptotic capacities and to reduce DNA-repair activity, to inhibit angiogenesis and tumor cell migration. This suggests the potential interest of the combination between anti-EGFR drugs and cytotoxic agents, especially ionizing radiation with promising results obtained at the clinical level in locally advanced HNC.
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Anticuerpos Monoclonales/uso terapéutico , Antineoplásicos/uso terapéutico , Receptores ErbB/antagonistas & inhibidores , Neoplasias de Cabeza y Cuello/tratamiento farmacológico , Proteínas de Neoplasias/antagonistas & inhibidores , Apoptosis , Terapia Combinada/métodos , Receptores ErbB/metabolismo , Neoplasias de Cabeza y Cuello/metabolismo , Neoplasias de Cabeza y Cuello/radioterapia , Humanos , Proteínas de Neoplasias/metabolismo , Neovascularización Patológica/prevención & controlRESUMEN
Recently we confirmed that latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV) accelerates a newly forming active c-Jun/Jun B heterodimer, a transcription factor, but little is known about the target gene regulated by it. In this paper, results indicated that a c-Jun/Jun B heterodimer induced by LMP1 upregulated cyclin D1 promoters activity and expression, on the contrary, downregulated p16, and maladjustment of cyclin D1 and p16 expression accelerated progression of cell cycle. Firstly, we found a c-Jun/Jun B heterodimer regulated synchronously and directly cyclin D1 and p16 in the Tet-on-LMP1-HNE2 cell line, in which LMP1 expression is regulated by Tet-on system. This paper investigated in depth function of the newly forming active c-Jun/Jun B heterodimer, and built new connection between environmental pathogenic factor, signal transduction and cell cycle.
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Ciclina D1/metabolismo , Inhibidor p16 de la Quinasa Dependiente de Ciclina/metabolismo , Proteínas Proto-Oncogénicas c-jun/metabolismo , Proteínas de la Matriz Viral/metabolismo , Carcinoma/metabolismo , Carcinoma/virología , Ciclo Celular , Línea Celular , Ciclina D1/genética , Inhibidor p16 de la Quinasa Dependiente de Ciclina/genética , Dimerización , Doxiciclina/farmacología , Humanos , Neoplasias Nasofaríngeas/metabolismo , Regiones Promotoras Genéticas/fisiología , Unión Proteica , Transducción de Señal , TransfecciónRESUMEN
The effects of QingKaiLing on the content of glutamate(Glu) and gamma-aminobutyric acid(GABA), and the numbers and affinity of N-methyl-D-aspartate (NMDA) receptor in brain tissue were observed. QingKaiLing did not change the content of Glu and GABA and the ratio of Glu/GABA in brain tissue (P > 0.05). The numbers of NMDA receptor on membrane of neuron were significantly decreased in QingKaiLing group(P < 0.05). These results suggested that the brain protective mechanism of QingKaiLing be in relation to decreasing the numbers of NMDA receptor.
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Encéfalo/metabolismo , Medicamentos Herbarios Chinos/farmacología , Ácido Glutámico/metabolismo , Fármacos Neuroprotectores/farmacología , Receptores de N-Metil-D-Aspartato/metabolismo , Animales , Femenino , Masculino , Distribución Aleatoria , Ratas , Ratas Sprague-Dawley , Ácido gamma-Aminobutírico/metabolismoRESUMEN
OBJECTIVE: To explore the effect of baicalin(BC) and dexamethasone(DXM) on interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha(TNF-alpha) in brain tissues of infectious brain edema. METHODS: The infectious brain edema model induced by pertussis bacilli(PB) was used. Brain water content(WC), content of Na+ and the levels of IL-1 beta, TNF-alpha were determined, and the morphological changes were observed under the light microscope. RESULTS: The results showed that the levels of WC, Na+, IL-1 beta and TNF-alpha in group PB were higher than those in group of normal saline(NS) (P < 0.01). And they were lower in groups BC and DXM than those in group PB(P < 0.05). In groups BC and DXM, there were no significant difference in the contents of water, Na+, IL-1 beta and TNF-alpha(P > 0.05). The water contents were positive linar correlated with IL-1 beta or TNF-alpha(P > 0.05). The water contents were positive linear correlated with IL-1 beta or TNF-alpha contents(r = 0.9381, 0.8349, P < 0.01). The structure of brain tissues in group NS was normal. In group PB, there were severe edema in brain tissues. In groups BC and DXM, the edema of brain tissues was reduced. CONCLUSIONS: The results suggest that the protective effect of BC and DXM against infectious brain edema were similar, the mechanism may be associated with the reduction of TNF-alpha and IL-1 beta.
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Edema Encefálico/metabolismo , Dexametasona/farmacología , Flavonoides/farmacología , Interleucina-1/metabolismo , Factor de Necrosis Tumoral alfa/metabolismo , Animales , Bordetella pertussis , Edema Encefálico/microbiología , Femenino , Masculino , Fármacos Neuroprotectores/farmacología , Distribución Aleatoria , Ratas , Ratas Sprague-Dawley , Tos Ferina/metabolismoRESUMEN
The purpose of this study was to determine the effect of infection brain edema (IBE) in the rat model induced by injecting pertussis bacilli (PB) into the left carotid artery. The specific binding of N-methyl-D-aspartate (NMDA) receptor with [3H] MK-801 was measured in the neuronal membrane of cerebral cortex. The Scatchard plots were performed. The Bmax values were 0.623 +/- 0.082 and 0.606 +/- 0.087 pmol/mg protein in the group that received normal saline (NS) and PB respectively (P < 0.05). The Kd values were 43.1 +/- 4.2 and 30.5 +/- 3.0 nM in the groups NS and PB respectively. The results indicated that the affinity of NMDA receptor was significantly higher in the group PB than group NS, whereas the total number of NMDA receptors had not changed in the IBE model. The increase of affinity of NMDA receptor can be blockaded by MK-801 pretreatment in vivo.
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Bordetella pertussis , Edema Encefálico/metabolismo , Encéfalo/metabolismo , Receptores de N-Metil-D-Aspartato/metabolismo , Tos Ferina/metabolismo , Animales , Edema Encefálico/microbiología , Modelos Animales de Enfermedad , Masculino , Ensayo de Unión Radioligante , Ratas , Ratas Sprague-Dawley , Tos Ferina/complicacionesRESUMEN
AIM: To study the effect of nimodipine (Nim) on infectious brain edema (BE). METHODS: An infectious BE model was induced by injection of Bordetella pertussis suspension (BPS) into right internal carotid artery in rabbits. Eighteen rabbits were randomly divided into 3 groups (n = 6). Group BE: BPS (0.6 mL.kg-1) was given; group NS: normal saline was given as control; group Nim: 10 min after injection of BPS, Nim, 10 micrograms.kg-1, was injected i.v. as a bolus followed by continuous infusion of 0.75 microgram.kg-1.min-1. All the rabbits were kept under observation for 4 h. Evans blue staining was assessed; water, calcium, calmodulin (Cal), and sodium contents were determined in the right brain. RESULTS: Nim vs BE: water 82.2 +/- 1.0% vs 84.4 +/- 1.2 (P < 0.01); calcium 10.5 +/- 1.3 mmol.kg-1 dry tissue vs 17.5 +/- 1.4 (P < 0.01); Cal 15.9 +/- 1.8 mumol.kg-1 wet tissue vs 24.0 +/- 3.0 (P < 0.01); sodium 173 +/- 7 mmol.kg-1 dry tissue vs 275 +/- 38 (P < 0.05). No significant difference for Evans blue staining between the two groups. CONCLUSION: Nim had beneficial effect on the infectious BE.