RESUMEN
AIMS AND BACKGROUND: This study retrospectively analyzes the use of chemotherapy in patients who died of advanced cancer either after having been in care at the Medical Oncology Unit (MOU) of the University Hospital of Bologna, Italy, or after having been assisted in their terminal disease phase by the Bologna Oncological Hospice at Home (OHH) of the Associazione Nazionale Tumori (ANT) Italia Foundation. In the latter group, the prescription and delivery of chemotherapy had been performed by doctors of medical oncology departments other than the MOU. RESULTS: Between January 2003 and September 2005, 793 deaths of patients were recorded (MOU: 312; OHH: 481). At least one cycle of chemotherapy had been received by 445 patients (56.1%). The most common cancer types were lung cancer (26.7%), colorectal cancer (14.8%), and breast cancer (11.2%). At the time of the last chemotherapy (I-CT), the median age of the patients was 68 years (range, 22-98 years) and the median KPS was 70 (range, 40-100). The median interval between I-CT and death was 71 days (range, 1-1913 days). One hundred and one patients (22.7%) had received their I-CT in the last 30 days of their life, 86% of them having intermediately chemosensitive (71%) or chemoresistant (14%) tumors. The I-CT in the last month of life was first line in 56% of cases and consisted of costly new-generation drugs in 36.6% of cases. CONCLUSIONS: The study suggests the urgent need to lay down guidelines for the appropriate use of chemotherapy in advanced cancer patients with a short life expectancy.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias Colorrectales/tratamiento farmacológico , Neoplasias Pulmonares/tratamiento farmacológico , Cuidado Terminal/tendencias , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Instituciones Oncológicas , Femenino , Guías como Asunto , Humanos , Pacientes Internos , Masculino , Oncología Médica/tendencias , Persona de Mediana Edad , Cuidados Paliativos/tendencias , Estudios Retrospectivos , Factores de TiempoRESUMEN
KIE: The chairman of the German Democratic Republic's (GDR) Committee on Medical Ethics, the Council of Medical Sciences, reviews issues of ethical concern to East German medicine. According to Tanneberger, ethical conflicts in health care are avoided in the GDR largely due to the socialist nature of public services. Ethical problems in medicine primarily involve research with human subjects, with animal experimentation and implementation of biomedical technologies as topics of interest as well. A nationwide system of ethical guidance and control has been created, headed by the Council of Medical Sciences and including the scientific councils of the individual medical disciplines and of the main research projects supported by the state, as well as the faculties of the medical universities. Tanneberger emphasizes that in the GDR, the intention is to develop a sense of responsibility among all those involved in medical research, rather than to impose a regulatory system.^ieng