RESUMEN
Phototherapy, represented by photodynamic therapy (PDT) and photothermal therapy (PTT), has great potential in tumor treatment. However, the presence of antioxidant glutathione (GSH) and the heat shock proteins (HSPs) expression caused by high temperature can weaken the effects of PDT and PTT. Here, a multifunctional nanocomplex BT&GA@CL is constructed to realize enhanced synergistic PDT/PTT. Cinnamaldehyde liposomes (CLs) formed by cinnamaldehyde dimer self-assembly were loaded with in gambogic acid (GA) and an aggregation-induced emission molecule BT to obtain BT&GA@CL. As a drug carrier, CL can consume glutathione (GSH) and release drugs responsively. The released BT aggregates can simultaneously act as both a photothermal agent and photosensitizer to achieve PDT and PTT under 660 nm laser irradiation. Specifically, GA as an HSP90 inhibitor can attenuate PTT-induced HSP90 protein expression, thereby weakening the tolerance of tumor cells to high temperatures and enhancing PTT. Such a multifunctional nanocomplex simultaneously modulates the content of GSH and HSP90 in tumor cells, thus enhancing both PDT and PTT, ultimately achieving the goal of efficient combined tumor suppression.
Asunto(s)
Glutatión , Liposomas , Fotoquimioterapia , Fármacos Fotosensibilizantes , Xantonas , Liposomas/química , Glutatión/metabolismo , Glutatión/química , Humanos , Fármacos Fotosensibilizantes/química , Fármacos Fotosensibilizantes/farmacología , Xantonas/química , Xantonas/farmacología , Animales , Ratones , Terapia Fototérmica , Línea Celular Tumoral , Neoplasias/tratamiento farmacológico , Neoplasias/terapia , Neoplasias/patología , Neoplasias/metabolismo , Proteínas HSP90 de Choque Térmico/metabolismo , Proteínas HSP90 de Choque Térmico/antagonistas & inhibidores , Proteínas HSP90 de Choque Térmico/química , Antineoplásicos/química , Antineoplásicos/farmacologíaRESUMEN
Accumulated reactive oxygen species (ROS) and their resultant vascular dysfunction in androgenic alopecia (AGA) hinder hair follicle survival and cause permanent hair loss. However, safe and effective strategies to rescue hair follicle viability to enhance AGA therapeutic efficiency remain challenging. Herein, we fabricated a quercetin-encapsulated (Que) and polydopamine-integrated (PDA@QLipo) nanosystem that can reshape the perifollicular microenvironment to initial hair follicle regeneration for AGA treatment. Both the ROS scavenging and angiogenesis promotion abilities of PDA@QLipo were demonstrated. In vivo assays revealed that PDA@QLipo administrated with roller-microneedles successfully rejuvenated the "poor" perifollicular microenvironment, thereby promoting cell proliferation, accelerating hair follicle renewal, and facilitating hair follicle recovery. Moreover, PDA@QLipo achieved a higher hair regeneration coverage of 92.5% in the AGA mouse model than minoxidil (87.8%), even when dosed less frequently. The nanosystem creates a regenerative microenvironment by scavenging ROS and augmenting neovascularity for hair regrowth, presenting a promising approach for AGA clinical treatment.
Asunto(s)
Alopecia , Folículo Piloso , Indoles , Polímeros , Quercetina , Especies Reactivas de Oxígeno , Alopecia/tratamiento farmacológico , Alopecia/patología , Quercetina/farmacología , Quercetina/administración & dosificación , Quercetina/química , Animales , Indoles/química , Indoles/farmacología , Folículo Piloso/efectos de los fármacos , Folículo Piloso/crecimiento & desarrollo , Polímeros/química , Ratones , Especies Reactivas de Oxígeno/metabolismo , Regeneración/efectos de los fármacos , Humanos , Cabello/efectos de los fármacos , Cabello/crecimiento & desarrollo , Proliferación Celular/efectos de los fármacos , Microambiente Celular/efectos de los fármacos , Modelos Animales de Enfermedad , MasculinoRESUMEN
We fabricated a potassium-ion battery by using 11,11,12,12-tetracyano-9,10-anthraquinonedimethane (TCAQ) as the cathode for the first time. Owing to the unique molecular structure and configuration of ionic liquid electrolytes, TCAQ shows a high redox potential of 2.6 V vs. K+/K while delivering a capacity of 88 mAh g-1 at a current density of 17 mA g-1 and a capacity retention of 61% after 50 cycles. The mechanism of the reaction of TCAQ with K was investigated. The results prove that TCAQ holds great promise for broad applications in potassium-ion batteries while revealing new scientific insights into K+-organic cathode batteries.