RESUMEN

The galectin family of proteins has high affinity with ß-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities. In recent years, a large number of studies have described the expression and correlation of galectins in different tumors. Each member of the family plays a vital role in tumor growth, progression, angiogenesis, adhesion, and tumor immune escape. Studies on the roles of galectins in lymphoma have mainly involved galectin-1, -3, -7, and -9. The results suggest that galectins may become novel targets for precise tumor treatment. This article reviews current research progress regarding galectins in lymphoma and provides new ideas for exploring them as novel targets for treating lymphoma and other important medical issues.

RESUMEN

Here, we present a method for the building of new bicyclic heterometallic cross-linked supramolecular polymers by hierarchical unification of three types of orthogonal noncovalent interactions, including platinum(II)-pyridine coordination-driven self-assembly, zinc-terpyridine complex, and host-guest interactions. The platinum-pyridine coordination provides the primary driving force to form discrete rhomboidal metallacycles. The assembly does not interfere with the zinc-terpyridine complexes, which link the discrete metallacycles into linear supramolecular polymers, and the conjugation length is extended upon the formation of the zinc-terpyridine complexes, which red-shifts the absorption and emission spectra. Finally, host-guest interactions via bis-ammonium salt binding to the benzo-21-crown-7 (B21C7) groups on the platinum acceptors afford the cross-linked supramolecular polymers. By continuous increase of the concentration of the supramolecular polymer to a relatively high level, supramolecular polymer gel is obtained, which exhibits self-healing properties and reversible gel-sol transitions stimulated by various external stimuli, including temperature, K+, and cyclen. Moreover, the photophysical properties of the supramolecular polymers could be effectively tuned by varying the substituents of the precursor ligands.

Asunto(s)

Sustancias Macromoleculares/química , Polímeros/química , Complejos de Coordinación/química , Éteres Corona/química , Luz , Sustancias Macromoleculares/efectos de la radiación , Platino (Metal)/química , Polímeros/efectos de la radiación , Piridinas/química , Zinc/química

RESUMEN

A series of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) with different connection sites and conjugation length and fluorene alternating conjugated polymers have been synthesized via palladium-catalyzed Suzuki coupling reaction. The polymers were fully characterized by 1H NMR spectroscopy and gel permeation chromatography (GPC), and their properties were measured by thermogravimetric analysis (TGA), UV-vis absorption spectroscopy, cyclic voltammetry (CV), photoluminescence (PL) spectroscopy, the Z-scan technique, and theoretical calculation using density-functional theory (DFT) method. The results indicate that the connection sites and conjugation length of BODIPY have great effect on the optical-electronic and nonlinear optical properties of the conjugated BODIPY- fluorene copolymers although they don't affect the polymerization process. The absorption and emission peaks of P1 exhibit red shifts compared to those of P2 and P3. The polymers show good nonlinear optical properties that are closely related to the connection sites of the BODIPY pendants. P1 exhibits relatively richer nonlinear optical (NLO) properties than P2 and P3. The third order nonlinear optical coefficient (χ(3)) of P1 is 3.57 × 10-11 esu, which is ~4 times larger than those of P2 and P3.

RESUMEN

Herein, we report the preparation of a multifunctional metallacage-core supramolecular gel by orthogonal metal coordination and host-guest interactions. A tetragonal prismatic cage with four appended 21-crown-7 (21C7) moieties in its pillar parts was first prepared via the metal-coordination-driven self-assembly of cis-Pt(PEt3)2(OTf)2, tetraphenylethene (TPE)-based sodium benzoate ligands and linear dipyridyl ligands. Further addition of a bisammonium linker to the cage delivered a supramolecular polymer network via the host-guest interactions between the 21C7 moieties and ammonium salts, which formed a supramolecular gel at relatively higher concentrations. Due to the incorporation of a TPE derivative as the fluorophore, the gel shows emission properties. Multiple stimuli responsiveness and good self-healing properties were also observed because of the dynamic metal coordination and host-guest interactions used to stabilize the whole network structure. Moreover, the storage and loss moduli of the gel are 10-fold those of the gel without the metallacage cores, indicating that the rigid metallacage plays a significant role in enhancing the stiffness of the gel. The studies described herein not only enrich the functionalization of fluorescent metallacages via elegant ligand design but also provide a way to prepare stimuli-responsive and self-healing supramolecular gels as robust and smart materials.

Asunto(s)

Complejos de Coordinación/química , Geles/química , Sustancias Macromoleculares/química , Compuestos Organoplatinos/química , Polímeros/química , Compuestos de Bencilideno/síntesis química , Compuestos de Bencilideno/química , Complejos de Coordinación/síntesis química , Éteres Corona/síntesis química , Éteres Corona/química , Fluorescencia , Geles/síntesis química , Sustancias Macromoleculares/síntesis química , Compuestos Organoplatinos/síntesis química , Polímeros/síntesis química , Reología

RESUMEN

Conjugated polymers containing distinct molecular units are expected to be very interesting because of their unique properties endowed by these units and the formed conjugated polymers. Herein, four new conjugated copolymers based on fluorene and 4,4'-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) have been designed and synthesized via Sonogashira polymerization. The fluorene unit was attached to the 3,5- or 2,6-positions of BODIPY by ethynylenes or p-diacetylenebenzene. The obtained polymers show good thermal stability and broad absorption in the wavelength range from 300 to 750 nm. The effects of site-selective copolymerization and conjugation length along the polymer backbone on the optoelectronic and electrochemical properties of these copolymers were systematically studied by UV-Vis spectroscopy, photoluminescence (PL) and cyclic voltammetry. Besides, it is found that the BODIPY-based copolymers exhibit selectively sensitive responses to cyanide anions, resulting in obvious change of UV-Vis absorption spectra and significant fluorescence quenching of the polymers among various common anions.

RESUMEN

Helical nano-ribbons with a large aspect ratio were obtained through the self-assembly of an achiral amphiphile. The symmetry breaking is attributed to the orderly but twisted stacking of terpyridine groups. In addition, the morphology of the assemblies can be tuned by the coordination between terpyridine and Zn(2+) ion.