RESUMEN

Diffuse mesangial sclerosis is a rare renal disease, occurring either in isolation or as part of Denys-Drash syndrome. Denys-Drash syndrome originates from mutations of the Wilms tumor suppressor gene (WT1 ). We describe the presence of WT1 mutations in 7 Japanese children with isolated diffuse mesangial sclerosis.

Asunto(s)

Genes del Tumor de Wilms/genética , Mesangio Glomerular/patología , Enfermedades Renales/genética , Mutación Puntual , Femenino , Humanos , Lactante , Recién Nacido , Japón , Enfermedades Renales/cirugía , Trasplante de Riñón , Masculino , Esclerosis