RESUMEN
AIM: The aim of the present study was to determine whether six weeks of submaximal endurance training using a cycle ergometer would result in a modified serum insulin-like growth factor-1 (IGF-1), an insulin-like growth factor binding protein 3 (IGFBP-3), and insulin resistance in middle-aged men with type 2 diabetes (T2D). METHODS: Twenty male patients with T2D voluntarily participated in this study and were randomly divided into two groups: the training group (N.=10) and the control group (N.=10). The training protocol consisted of a 45-minutes cycling session/day, three days/week for six weeks with intensity 60-70% of the maximum heart rate. To examine the IGF-1 and the IGFBP-3, fasting blood glucose levels, and insulin resistance, blood sampling was performed before and immediately after the first and 18th sessions. The homeostatic model assessment (HOMA-IR) method was used to determine insulin resistance. RESULTS: Before the study began, no significant difference between the two groups was observed in the anthropometric and blood factors. After a session of aerobic exercise, IGF-1 and IGFBP-3 levels were significantly increased (153.79% and 64.3%, respectively), and fasting glucose and insulin resistance levels were significantly decreased (15.82% and 27.82%, respectively); however, the changes resulting from a six-week training period were not significant. CONCLUSION: According to the present study, one session of aerobic exercise for middle-aged men with T2D leads to increased IGF-1 and IGFBP-3, and to decreased fasting glucose and insulin resistance. Considering the lack of changes after a six-week training, it seems that the amount of change depends on subjects' fitness level and exercise parameters. From a clinical point of view, the beneficial effects of acute exercise inT2D subjects show that such exercises should be part of the daily program for them.
Asunto(s)
Diabetes Mellitus Tipo 2/sangre , Diabetes Mellitus Tipo 2/fisiopatología , Ejercicio Físico/fisiología , Resistencia a la Insulina/fisiología , Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina/sangre , Factor I del Crecimiento Similar a la Insulina/análisis , Glucemia/análisis , Humanos , Masculino , Persona de Mediana Edad , Resistencia Física/fisiología , Distribución AleatoriaRESUMEN
In this letter, by design of Complex Morlet Wavelet and Complex Frequency B-Spline Wavelet and linearly combining them, a novel approach, Hybrid Complex Wavelet, has been proposed to identify and detect the components of ECG signal such as QRS complex and R peak. By train and test of implementing the proposed method on both clinically recorded signals from 40 patients and 30 signals of MIT BIH database, we reached better recognition accuracy in comparison to other well-known approaches.