RESUMEN
The intravenous (IV) usage of diuretics such as furosemide may cause changes in clinical variables, electrocardiographic (ECG) indices and some serum electrolytes concentrations in miniature donkeys. The purpose of this study was to evaluate the effects of double intravenous (IV) administration of furosemide at different doses on the clinical variables, ECG indices and serum electrolytes levels in miniature donkeys. A total of 21 clinically and para-clinically healthy miniature donkeys with a mean age of 6.00 ± 1.00 years and weight of 95.00 ± 5.00 kg were used. The animals were randomly divided into three groups of control (normal saline) and low- (1.00 mg kg-1) and high-dose (2.00 mg kg-1) of furosemide. Two IV injections with 12-hr interval were administered in each animal. The clinical and ECG parameters were measured at 0 (baseline), 2 (T2), 24 (T24) and 48 (T48) hr after drug administration. Serum concentrations of electrolytes were measured at T0, T24 and T48. The results of this study showed no changes in clinical variables (heart rate, rectal temperature and respiratory rate) and ECG indices (amplitude and duration of P, QRS and T waves and duration of PR, QT and RR intervals) as well as no significant changes in serum electrolytes (sodium, potassium, chloride, phosphorus, calcium and magnesium) levels. Although no significant effect on clinical variables, electrolytes levels and ECG indices after double IV administration of furosemide (1.00 and 2.00 mg kg-1) in miniature donkeys was observed, absence of these effects does not mean that furosemide had no pharmacological effect.
RESUMEN
The objective of this study was to comparatively evaluate the anti-inflammatory effects of intravenous administration of insulin (in different doses) and flunixin on physiological variables, acute-phase responses, and cardiovascular biomarkers during inflammatory phase which was induced by Escherichia coli lipopolysaccharide (LPS) serotype O55:B5 in miniature donkeys. A total of twenty-four clinically healthy male adult miniature donkeys aged 5 ± 1 year and weighing 120 ± 10 kg were studied. The animals were assigned randomly to four experimental groups (three treatment and one positive control groups). Six hours after induction of inflammatory phase (by 20 ng kg-1 LPS), donkeys in groups Insln 1.5, Insln 3, and Flnx received insulin at 1.5 IU kg-1, insulin at 3 IU kg-1, and flunixin at 2.2 mg kg-1, respectively. Animals in the positive control group were assigned to receive LPS without any anti-inflammatory drugs. We have shown that serum concentrations of cardiovascular, acute-phase proteins and cytokines were increased during inflammatory phase in miniature donkeys. Our results revealed that insulin at 3 IU kg-1 as well as flunixin at 2.2 mg kg-1 can improve almost all of the physiological variables and hematobiochemical variables (including serum concentrations of tumor necrosis factor-alpha, interferon-gamma, haptoglobin, serum amyloid A, cardiac troponin I, hemocysteine, white blood cell, and packed cell volume) after 24 hours. Unlike insulin at 1.5 IU kg-1, insulin at 3 IU kg-1 may be considered useful for inflammatory conditions in miniature donkeys.
Asunto(s)
Reacción de Fase Aguda/veterinaria , Equidae , Insulina , Animales , Antiinflamatorios , Biomarcadores , Clonixina/análogos & derivados , MasculinoRESUMEN
To evaluate the effects of season, sex and age on serum concentrations of thyroid hormones, cholesterol and triglyceride, and their correlations together in dromedarian camels, these parameters were measured in 180 clinically healthy dromedary camels. No significant difference was detected for the measured serum parameters between the two sexes and among the different age groups of camels and none of them had significant correlation with the age of the animals. There was a significant correlation between serum T4 and triglyceride (r = -0.243, p = 0.002). There were significant differences between summer and winter seasons in the serum concentrations of T4 (p < 0.001), T3 (p = 0.01) and triglyceride (p < 0.001). In winter, the serum concentration of triglyceride had a significant correlation with the age of the sampled camels (r = -0.235, p = 0.026). In male camels,T4 had a marginally significant correlation with cholesterol (r= -0.158, p = 0.06).The effects of season, sex and age on the serum concentrations and relationships between thyroid hormones, cholesterol and triglyceride in dromedary camels can be proposed as the probable causes of the controversial findings in the previous studies.
RESUMEN
To study the effects of concurrent infection of Cryptosporidium parvum with rotavirus and coronavirus in comparison to single infection of rotavirus and coronavirus, electrocardiographic parameters and serum electrolytes and microelements are compared between eight calves with concurrent infection and ten calves with single infection. Calves with single infections had higher serum concentrations of sodium and calcium, and less potassium, copper, and iron, which was not statistically significant. They also had significantly shorter P and QRS wave amplitudes and longer T wave duration in electrocardiogram patterns.
RESUMEN
To evaluate the serum concentrations of haptoglobin (Hp) and serum amyloid A (SAA) in water buffaloes with abomasal ulcers, the abomasums of 100 randomly selected water buffaloes were examined after slaughter. Type I abomasal ulcers were found in 56 out of 100 buffaloes. Serum concentrations of Hp and SAA were measured. There was no significant difference between affected and non-affected buffaloes in the serum concentrations of Hp and SAA. The serum concentrations of Hp and SAA had no significant correlation with age and the serum SAA revealed no significant correlation with the number of abomasal ulcers. A significant correlation was found between the serum Hp and the number of abomasal ulcers (r =0.29, p = 0.04). There was no significant difference in the serum concentrations of Hp and SAA between buffaloes with different ulcer locations in the abomasums. Although more work on a larger number of animals is required in this area, it seems that the measurement of the serum Hp can be used to predict the abundance of type I abomasal ulcers.