RESUMEN
541 workers with long-term history of occupational contact with antibiotics and chemicals were examined by a dermatologist, ENT specialist, neuropathologist, surgeon, ophthalmologist. Many workers complained of occasional skin eruption, rhinitis, skin itching, sneezing, cough, Quincke's edema. Allergic examination revealed the presence of allergic symptoms (allergic dermatitis, itch, vasomotor rhinitis, chronic eczema, obstructive bronchitis, bronchial asthma, Quincke's edema, acute and chronic conjunctivitis) in 98 examinees. Somatic affections are represented by hypertension, chronic hepatitis, ulcer.
Asunto(s)
Antibacterianos/efectos adversos , Industria Farmacéutica , Exposición Profesional/efectos adversos , Adulto , Hipersensibilidad a las Drogas/diagnóstico , Hipersensibilidad a las Drogas/etiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/inducido químicamente , Enfermedades Profesionales/diagnóstico , Federación de RusiaAsunto(s)
Hipersensibilidad a las Drogas/diagnóstico , Susceptibilidad a Enfermedades , Hipersensibilidad a las Drogas/etiología , Hipersensibilidad a las Drogas/inmunología , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Humanos , Inmunidad Celular/efectos de los fármacos , Pruebas Inmunológicas/métodosAsunto(s)
Hipersensibilidad a las Drogas/diagnóstico , Desensibilización Inmunológica , Hipersensibilidad a las Drogas/etiología , Hipersensibilidad a las Drogas/terapia , Humanos , Hipersensibilidad Inmediata/inducido químicamente , Hipersensibilidad Inmediata/diagnóstico , Hipersensibilidad Inmediata/terapiaRESUMEN
A regular medical examination of 234 workers at a chemical pharmaceutical factory was performed. Skin rash, rhinitis and bronchospasm were detected in 7.3% of the examinees. A microthermal method was applied to 69 workers engaged in antibiotic production. In 26% the results were conditionally positive, in 7.6%--sharply positive. Preclinical diagnosis of drug allergy under occupational conditions made it possible to consider properly the problems of effective employment of the workers preserving their working capacity.
Asunto(s)
Hipersensibilidad/diagnóstico , Enfermedades Profesionales/diagnóstico , Adulto , Femenino , Humanos , Masculino , Persona de Mediana EdadAsunto(s)
Antibacterianos/efectos adversos , Adulto , Vía Clásica del Complemento/efectos de los fármacos , Proteínas del Sistema Complemento/análisis , Industria Farmacéutica , Tolerancia a Medicamentos , Exposición a Riesgos Ambientales , Femenino , Humanos , Masculino , Persona de Mediana Edad , U.R.S.S.RESUMEN
The presence of the lymphocyte migration inhibition factor consequent upon sensitization of the organism to the antigen of denaturalized protein of the heart muscle was studied in 72 patients with myocardial infarction and in 40 healthy individuals. It was established that the migration inhibition factor appears in the blood 6 hours after the occurrence of myocardial infarction. The migration index is 52 +/- 2% in such patients and no less than 90% in the controls.
Asunto(s)
Infarto del Miocardio/diagnóstico , Adulto , Anciano , Angina de Pecho/inmunología , Antígenos/inmunología , Inhibición de Migración Celular , Diabetes Mellitus/inmunología , Femenino , Humanos , Hipertensión/inmunología , Factores Inhibidores de la Migración de Leucocitos/sangre , Leucocitos/inmunología , Masculino , Persona de Mediana Edad , Infarto del Miocardio/inmunología , Miocardio/inmunologíaRESUMEN
Humoral and cellular immunological paramaters were studied in 3 groups of patients with ischemic heart disease. A distinct correlation was revealed between these parameters and clinical symptoms of the disease. It was shown that an immunological reconstruction took place already in the ischemic stage of coronarosclerosis. This reconstruction is expressed by the growth of hemagglutinating and precipitating antibody titers, as well as by the emergence of sensitized lymphocytes and excretion of the lymphocyte migration inhibiting factor. The use of various homogenates (a normal or atherosclerotic aorta, an infarctial myocardium) or the nonspecific mitogen PHA showed the presence of a specific antigenoactive complex in the blood of patients with ischemic heart disease. The complex was capable of penetrating and affecting the vascular wall as well as of producing antitissular (antivascular) antibodies which, together with the other factors, can help lipoprotein penetration through the arterial wall to form atheromatous plaques.