RESUMEN
In an in vitro human myometrial strip system, both relaxin and progesterone can independently decrease the amplitude of spontaneous myometrial contractions. However, progesterone and relaxin synergize in this action. Doses of relaxin and progesterone which independently are ineffective, together inhibit myometrial contraction amplitude. Relaxin and progesterone are both products of the corpus luteum, a structure necessary for early pregnancy maintenance. The synergistic action of relaxin and progesterone in vitro suggests a similar in vivo physiologic effect in establishing uterine quiescence.
Asunto(s)
Progesterona/farmacología , Relaxina/farmacología , Contracción Uterina/efectos de los fármacos , Adulto , Cuerpo Lúteo/fisiología , Sinergismo Farmacológico , Femenino , Humanos , Técnicas In VitroAsunto(s)
Aborto Espontáneo/sangre , Gonadotropina Coriónica/sangre , Relaxina/sangre , Femenino , Humanos , Embarazo , RadioinmunoensayoRESUMEN
A 31-year-old woman developed unilateral endometriosis at the site of ovarian implantation to a uterine window. This complication of the Estes procedure resembles the experimental endometriosis induced in rhesus monkeys by causing intraabdominal menstruation. This adds support to the Sampson hypothesis of endometriosis development.
Asunto(s)
Endometriosis/etiología , Enfermedad Iatrogénica , Neoplasias Uterinas/etiología , Adulto , Femenino , Humanos , Trastornos de la Menstruación/complicaciones , Ovario/cirugíaRESUMEN
Relaxin is a peptide hormone secreted by the human corpus luteum of pregnancy . Aqueous extracts of relaxin-rich pregnancy corpora lutea decreased the amplitude of spontaneous human myometrial strip contractions in vitro. Relaxin-poor extracts of menstrual cycle corpora lutea did not affect contractions. Antibody precipitation of relaxin from pregnancy luteal extracts eliminated the effect on myometrial strips. Relaxin removal was confirmed by bioassay. This demonstrates an inhibiting action of human relaxin on human myometrial tissue in vitro. This action suggests a mechanism for maintaining uterine quiesence in early pregnancy.
Asunto(s)
Embarazo , Relaxina/farmacología , Contracción Uterina/efectos de los fármacos , Cuerpo Lúteo/análisis , Depresión Química , Femenino , Humanos , Técnicas In Vitro , Menstruación , Miometrio/efectos de los fármacos , Relaxina/análisisAsunto(s)
Trompas Uterinas/anomalías , Embarazo Tubario/etiología , Útero/anomalías , Adulto , Femenino , Humanos , EmbarazoRESUMEN
Relaxin is a peptide hormone produced by the corpus luteum during pregnancy in human beings. There are no extraluteal sites of production of relaxin in women. By means of a heterologous porcine radioimmunoassay, serial serum relaxin concentrations were determined in three women throughout pregnancy and into labor. All three demonstrated a first-trimester elevation followed by a second-trimester decline; values then remained stable throughout the second and third trimesters and into labor. This further confirms the functional activity of the corpus luteum throughout pregnancy and the value of relaxin as an index of luteal function during gestation.