1.
Pharmacol Toxicol
; 72(1): 22-4, 1993 Jan.
Artículo
en Inglés
| MEDLINE
| ID: mdl-8441736
RESUMEN
The inhibitory effect of cyclophosphamide hydrolysis product (CPHP) on vitamin B12 binding ability to proteins has been established. The ester N-(2-chloroethyl)-N'-(3-phosphopropyl)-ethylenediamine hydrochloride is probably responsible, in vitro, for blocking the protein binding sites. Preincubation of proteins with vitamin B12 prevents the inhibitory effect of CPHP.