RESUMEN

Interleukin-6, a multifunctional cytokine upon binding to its receptor on hepatocytes regulates production of acute phase proteins involved in local and systemic inflammation. Gene expression and biosynthesis of IL-6 and its receptor (IL-6 R/gp130) is under complex regulation. Histamine, in addition to its principal role in immediate type hypersensitivity has been described to modulate IL-6 production and expression of IL-6 receptor. In this study, the IL-6 and IL-6 receptor expression was examined in histamine deficient histidine decarboxylase (HDC) knock-out mouse model. Our data suggest that in histamine deficient mice the inducibility of IL-6 is significantly reduced, whilst more IL-6 receptor/gp130 mRNA expresses in the liver than in wild type (HDC(+/+)) mice. These in vivo findings confirm earlier in vitro results and emphasize the efficacy of antihistamines in local IL-6 related processes.

Asunto(s)

Regulación de la Expresión Génica , Histamina/metabolismo , Histidina Descarboxilasa/deficiencia , Interleucina-6/metabolismo , Receptores de Interleucina-6/metabolismo , Animales , Antígenos CD/genética , Antígenos CD/metabolismo , Receptor gp130 de Citocinas , Eliminación de Gen , Frecuencia de los Genes , Histamina/genética , Histidina Descarboxilasa/genética , Histidina Descarboxilasa/metabolismo , Interleucina-6/sangre , Subunidad alfa del Receptor del Factor Inhibidor de Leucemia , Hígado/metabolismo , Glicoproteínas de Membrana/genética , Glicoproteínas de Membrana/metabolismo , Ratones , Ratones Noqueados , ARN Mensajero/genética , ARN Mensajero/metabolismo , Receptores de Citocinas/genética , Receptores de Citocinas/metabolismo , Receptores de Interleucina-6/genética , Receptores OSM-LIF