RESUMEN
Currently, plasma medicine is a synthetic direction that unites the efforts of specialists of various profiles. For the successful formation of plasma medicine, it is necessary to solve a large complex of problems, including creating equipment for generating cold plasma, revealing the biological effects of this effect, as well as identifying and justifying the most promising areas of its application. It is known that these biological effects include antibacterial and antiviral activity, the ability to stimulate hemocoagulation, pro-regenerative properties, etc. The possibility of using the factor in tissue engineering and implantology is also shown. Based on this, the purpose of this review was to form a unified understanding of the biological effects and biomedical applications of argon cold plasma. The review shows that cold plasma, like any other physical and chemical factors, has dose dependence, and the variable parameter in this case is the exposure of its application. One of the significant characteristics determining the specificity of the cold plasma effect is the carrier gas selection. This gas carrier is not just an ionized medium but modulates the response of biosystems to it. Finally, the perception of cold plasma by cellular structures can be carried out by activating a special molecular biosensor, the functioning of which significantly depends on the parameters of the medium (in the field of plasma generation and the cell itself). Further research in this area can open up new prospects for the effective use of cold plasma.
RESUMEN
This overview shows the mapping of specific visualization techniques, depth assessment of the structure of the underlying tissues and used wavelengths of radiation. Medical imaging is currently one of the most dynamically developing areas of medical science. The main aim of the review is a systematization of information on the current status of the microwave imaging of biological objects, primarily of body tissues. The main options of microwave sensing of biological objects are analyzed. Two basic techniques for sensing differing evaluation parameters are characterized. They are microwave thermometry (passive) and near-field resonance imaging. The physical principles of microwave sensing application are discussed. It is shown that the resonant near-field microwave tomography allows visualization of the structure of biological tissues on the basis of the spatial distribution of their electrodynamic characteristics - permittivity and conductivity. Potential areas for this method in dermatology, including dermatooncology, are shown. The known results of applying the method to patients with dermatoses are given. The informativeness of the technology in the early diagnosis of melanoma is shown. The prospects of microwave diagnostics in combustiology, reconstructive and plastic surgery are demonstrated. Thus, microwave sensing is a modern, dynamically developing method of biophysical assessment of body tissues. There is a strong indication of the feasibility of application of microwave sensing in combustiology (in different periods of burn disease), as well as in reconstructive surgery. Further research in this and other areas of biomedicine will significantly expand the range of possibilities of modern technologies of visualization.