RESUMEN
Five years after single intravenous injection of a mixture of 239Pu and 90Sr to semifine-wool sheep (7.4 kBq/kg + 185 kBq/kg) the iodine-fixing and hormone secreting functions of the thyroid gland were inhibited; where 90Sr alone was injected in the above dose inhibited was the hormone-secreting function only. Since 239Pu alone did not cause such alterations, the observed remote effect was attributed to the effect of the incorporated 90Sr.
Asunto(s)
Plutonio/administración & dosificación , Radioisótopos de Estroncio/administración & dosificación , Glándula Tiroides/efectos de la radiación , Animales , Estudios de Seguimiento , Inyecciones Intravenosas , Ovinos , Glándula Tiroides/fisiología , Hormonas Tiroideas/sangre , Factores de TiempoRESUMEN
Haptoglobin (Hp) phenotypes were determined by thin-layer polyacrylamide gel electrophoresis in 2071 normal Russians, Tatars, and Bashkirs. Hp phenotype distribution was found similar in these populations, making up 13.4% for Hp 1-1, 48% for Hp 1-2, 38.6% for Hp 2-2. Hp1 gene incidence (0.37) was characteristic of the European populations. Serum alkaline phosphatase and gamma-glutamyl transpeptidase activities were similar in all the three Hp phenotypes. Alanine and aspartate aminotransferases and acid phosphatase activities were higher in Hp 1-1 phenotype by 25, 15, and 15 percent, respectively.
Asunto(s)
Enzimas/sangre , Etnicidad , Haptoglobinas/genética , Humanos , Fenotipo , U.R.S.S./etnologíaRESUMEN
Levels of gamma-glutamyltranspeptidase and total, alpha 2 and alpha 1-alkaline phosphatase versus dissemination pattern and survival time were studied in patients with stage III and IV tumors of various sites. No significant changes in the activity of the said enzymes were registered in cases of single hepatic metastasis and metastasis-free liver. A slight increase in the enzymes' activity was observed in patients with pronounced liver involvement within months 10-4 before death. That was followed by a sharp and marked (3-4 times normal) rise in the levels during months 4-3. Changes in enzyme activity within the terminal 12 months were described with the aid of polynoms on the basis of regression analysis. A correlation between liver mass and degree of rise in serum enzymes levels was established.
Asunto(s)
Fosfatasa Alcalina/sangre , Pruebas Enzimáticas Clínicas , Metástasis de la Neoplasia/diagnóstico , gamma-Glutamiltransferasa/sangre , Humanos , Neoplasias Renales/diagnóstico , Neoplasias Renales/secundario , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/secundario , Neoplasias Pulmonares , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/secundario , Pronóstico , Análisis de Regresión , Neoplasias GástricasRESUMEN
Serum creatine-kinase activity was above the upper normal limit in 40-80% of the 632 patients admitted to hospital for angina pectoris and deteriorating essential hypertension. The highest (4-6-fold) increase over the mean control values was associated with myocardial ischemia, paroxysmal tachycardia and hypertensive crises. Intramuscular injections were shown to be unrelated to increased incidence or magnitude of creatine-kinase activation in the examined patients. Creatine-kinase levels were particularly high in cases of cerebral stroke (a 7-fold increase above normal) and alcoholic cardiopathies (a 8-fold increase).
Asunto(s)
Enfermedades Cardiovasculares/enzimología , Creatina Quinasa/sangre , Angina de Pecho/enzimología , Cardiomiopatía Alcohólica/enzimología , Humanos , Hipertensión/enzimología , Cardiopatía Reumática/enzimologíaRESUMEN
An examination of 400 coronary patients demonstrated a relationship between increased serum CPK, AST, LDH and LDH-1, and the spread and severity of myocardial infarction (MI). In transmural and large-focal MI, CPK activity peak observed on Day 1-2 of the disease was increased 4-12-fold, and that of AST, 5-fold, as compared to the upper limit of the normal range. In small-focal and subendocardial MIs, the increase was 1.5-8-fold and 3-fold, respectively. In angina pectoris, serum CPK activity also showed an increase, although a less manifest one. A CPK activity level of 175 IU is proposed as a discriminative level to be used in the diagnosis of large-focal myocardial infarctions.