RESUMEN
Malabsorption syndrome (MAS) is a common condition in India. In Indian adults, tropical sprue and celiac disease are leading causes of MAS. Sometimes, the diagnosis of MAS may pose a challenge due to the varied signs and symptoms. We present a case of MAS in a young female, whose presenting symptoms were mainly neurological. She was successfully treated under regular follow-up for the past 6 years without any symptoms.
RESUMEN
INTRODUCTION: Polycystic ovarian syndrome (PCOS) is common among women of reproductive age. Although traditional cardiac risk factors are known to be altered and improved with short-term metformin therapy, not much is known about novel cardiac risk factors. OBJECTIVE: The aim of this study was to evaluate the effects of lifestyle modification and short-term metformin therapy on the fasting serum lipids, homeostasis model assessment of insulin resistance (HOMA-IR), serum high-sensitivity C-reactive protein (hsCRP), and serum homocysteine. METHODS: Native overweight [body mass index (BMI) >23 kg/m(2)] Indian women diagnosed with PCOS were evaluated and subjected to an oral glucose tolerance test and determination of insulin, homocysteine, hsCRP, and fasting lipids levels. They were started on maximally tolerated doses of metformin along with lifestyle modification. Following 3 months of therapy, they were resampled. RESULTS: Out of 36 consecutive patients included, 25 women completed 3 months of metformin treatment and were eligible for repeat evaluation. The age of study group was 22.2 ± 5 years. Twenty-two (61%) women were obese (BMI >25 kg/m(2)). Improvement was seen in body weight, BMI, serum total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), hsCRP, and serum testosterone on metformin therapy. However, no improvement was seen in serum fasting insulin, HOMA-IR, or homocysteine. CONCLUSION: Serum hsCRP improved with lifestyle modification and metformin therapy for 3 months in overweight subjects from India with PCOS, along with serum total cholesterol, triglycerides, and HDL-C. However, markers of insulin resistance and serum homocysteine did not improve.
Asunto(s)
Enfermedades Cardiovasculares/tratamiento farmacológico , Hipoglucemiantes/uso terapéutico , Estilo de Vida , Metformina/uso terapéutico , Sobrepeso/tratamiento farmacológico , Síndrome del Ovario Poliquístico/tratamiento farmacológico , Adolescente , Adulto , Proteína C-Reactiva/metabolismo , Femenino , Homeostasis , Homocisteína/sangre , Humanos , Insulina/sangre , Resistencia a la Insulina , Lípidos/sangre , Lípidos/química , Dosis Máxima Tolerada , Radioinmunoensayo/métodos , Factores de RiesgoRESUMEN
INTRODUCTION AND AIM OF THE STUDY: To document abnormalities on spirometry in patients with type1 diabetes mellitus (DM) and to study the determinants of these. MATERIAL AND METHODS: Thirty nine patients attending the type 1 DM clinic underwent spirometry. The absolute FEV1 and FVC were compared with the predicted ones and expressed as a percentage of the predicted. Additional information collected included gender, age, weight, height and the latest glycated hemoglobin. Data were presented as mean±SD.χ2 test was used to study differences in proportions and Pearson's coefficient was calculated for correlations. RESULTS: Twenty patients (51.2%) had pulmonary function abnormalities, of which 17 patients had a restrictive pattern on spirometry and 3 had an obstructive pattern. Of all the patients, 45.8% were stunted, i.e. had the height SDS <-2 SD while 25.7% were extremely stunted (height SDS < -3). Sevenof 9 (77.8%) patients with extreme stunting (Ht SDS <-3) had restrictive ventilatory disturbances, whereas only 8 of 26 (30.7%) persons with Ht SDS above -3 had the same (p <0.05). CONCLUSIONS: Spirometric abnormalities are common in type 1 DM and stunting is a significant determinant of the same.