1.
J Pediatr Hematol Oncol
; 36(3): e202-6, 2014 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24072248
RESUMEN
Ectopic production of ß-human chorionic gonadotropin (ß-hCG) by nontrophoblastic tumors has been reported but mostly in carcinomas. We report a case of an adolescent female patient with a epithelioid osteosarcoma that was discovered to secrete ß-hCG after routine pregnancy testing. Immunohistochemical staining of her primary tumor biopsy demonstrated immunoreactivity for ß-hCG. Levels of serum ß-hCG were monitored throughout her therapy and demonstrated normalization with effective systemic therapy and local control. She remains disease free 6 months off therapy, with undetectable hormone levels. A review of the available literature on ß-hCG production by sarcomas is also presented.
Asunto(s)
Biomarcadores de Tumor/metabolismo , Neoplasias Óseas/metabolismo , Gonadotropina Coriónica Humana de Subunidad beta/metabolismo , Osteosarcoma/metabolismo , Sarcoma/metabolismo , Adolescente , Neoplasias Óseas/tratamiento farmacológico , Neoplasias Óseas/patología , Femenino , Humanos , Técnicas para Inmunoenzimas , Osteosarcoma/tratamiento farmacológico , Osteosarcoma/patología , Embarazo , Pruebas de Embarazo , Pronóstico , Sarcoma/tratamiento farmacológico , Sarcoma/patología
2.
Belmont; Thomson Brooks/Cole; 2006. 652 p. tab.
Monografía
en Inglés
| Coleciona SUS
| ID: biblio-935867
3.
Belmont; Thomson Brooks/Cole; 2006. 652 p. tab.
Monografía
en Inglés
| LILACS
| ID: lil-598002