RESUMEN

OBJECTIVES: Carcinoembryonic antigen (CEA) is a broad-spectrum tumor marker for differential diagnosis, monitoring, and response assessment of a variety of malignancies. This meta-analysis was aimed at evaluating whether serum CEA could predict the prognosis in patients with colorectal cancer liver metastasis (CRCLM) before and after liver resection (LR). METHODS: PubMed, Embase, Cochrane, and Web of Science were systematically searched to retrieve literature, with a search cutoff date of 27 February 2023. Articles were strictly screened for inclusion according to pre-specified inclusion and exclusion criteria. Data were pooled and analyzed using Stata 16.0. RESULTS: This meta-analysis included 36 studies involving a total of 11 143 CRCLM patients. The results showed that a high pre-LR serum CEA level was correlated with poor overall survival (OS: HR = 1.61, 95% CI = 1.49-1.75, P < 0.001) and recurrence-free survival (RFS: HR = 1.27, 95% CI = 1.11-1.45, P < 0.001) in CRCLM patients. A high post-LR serum CEA level predicted poor overall survival (OS: HR = 2.66, 95% CI = 2.10-3.38, P < 0.001). CONCLUSION: High preoperative and postoperative serum CEA levels in patients with CRCLM were significantly associated with poor prognosis, independent of treatment modality, mode of analysis, case origin, and cutoff value classification.

RESUMEN

Despite considerable interest in the Japanese population in receiving the vaccine for COVID-19 when it first became available, a sizable percentage of people remain unwilling or hesitant to be vaccinated. Concerns among both the vaccinated and the unwilling center on the vaccine's efficacy and its safety. Thus, this study aimed to identify whether the willingness to receive COVID-19 vaccination is related to the sources of information people use to learn about the vaccine. A cross-sectional study was conducted on 800 participants registered in an Internet research panel across Japan who completed a questionnaire on their sources of information about the vaccine, demographics, and vaccination status. Vaccine willingness/hesitancy and refusal were set as dependent variables in the logistic regression analysis, with sources of vaccine information and other socio-demographic variables set as independent variables. The results of the analysis found that the information sources significantly associated with willingness to vaccinate were TV (AOR 2.44 vs. vaccine refusal/hesitation), summary websites of COVID-19 by non-experts (AOR 0.21, vs. vaccine refusal/hesitation), Internet video sites (AOR 0.33, vs. vaccine refusal/hesitation), and the personal websites of doctors (AOR 0.16, vs. vaccine refusal/hesitation). Given the likelihood of misinformation in non-traditional sources of information, it is important that health communications be accurate and persuasive.

RESUMEN

Introduction Coronavirus disease 2019 (COVID-19) vaccine hesitancy has become a global problem. Therefore, we aimed to determine the relationship between the information sources on vaccines and the willingness of people to be vaccinated in Thailand. Methods A sample of 500 respondents was drawn from an Internet research panel, and a questionnaire survey was administered to evaluate respondents' willingness to be vaccinated by sex, age group, educational background, occupation, and presence of chronic diseases, as well as their information sources on COVID-19 vaccines. Descriptive statistics and logistic regression analysis were employed to assess the relationship between vaccine hesitancy/refusal and other variables. Results Our results demonstrated that 90.2% of the participants were either willing to vaccinate or were already vaccinated. By contrast, 6.0% were hesitant and 3.8% did not want to be vaccinated. Females, people with education less than master's/bachelor's degree or high school, day laborers, housewives, and unemployed were significantly related to vaccine hesitation/refusal. Furthermore, they were less likely than the vaccine willingness group to use information resources from the Ministry of Health, public health centers, or medical associations. Conclusions As vaccine hesitancy and refusal ratio were found to be substantially lower than in a previous study for Thailand and other countries, public authorities should poll the public to identify vaccine-hesitant populations and their reasoning and provide appropriate information directly to the general public.

RESUMEN

This study aimed to establish the quality of life and mental health status among older Japanese people living in Chiang Mai, Thailand. We conducted a questionnaire survey among Japanese retired people aged 50 years or over who had been living in Thailand. The questionnaire covered socio-demographic variables including health status and ability to communicate in Thai. We measured mental health status using the Japanese version of the General Health Questionnaire-28 (GHQ-28) and quality of life using the Japanese version of EuroQOL-5D-3L. We explored the factors associated with poor mental health and quality of life using logistic regression analysis. In total, 96 (89.7%)participants provided complete responses. Overall, quality of life was generally good, although those with one or more chronic diseases reported significantly lower quality of life. Having one or more chronic diseases and being aged 70-79 were significantly associated with poorer mental health. In total, 21 (21.8%) respondents had a possible neurosis, which was defined as a total GHQ-28 score of more than 6. The logistic regression analysis showed a significant association between possible neurosis and the presence of chronic diseases (adjusted odds ratio: 11.7 1). Quality of life among older Japanese people living in Chiang Mai was generally good, but there was a high level of possible neurosis, especially among those with one or more chronic diseases.

RESUMEN

The aim of this study was to describe patterns and potential risk factors for sleep disturbances, including that of sleep apnea, among Thai registered nurses. A descriptive, cross-sectional design was implemented. A sample of 233 registered nurses was recruited from 10 nursing departments from a tertiary hospital. Participants completed a one-time, self-report questionnaire and a 1 week-long sleep diary. Descriptive and logistic regression statistics were used for the analysis. Approximately 76% of nurses slept less than 7 h, 12.3% had difficulty initiating sleep, and 5% had difficulty maintaining sleep. Short sleep duration was prevalent, and night shift work schedules that exceeded 10 episodes/month were perceived as contributing to difficulties with initiating sleep. After excluding males from the analysis, the risk for depression related to short sleep duration becomes statistically significant. Organizational policies for registered nurses' shift work should include effective management of night shift assignments, as well as interventional strategies and policy directions, to promote sleep quality and mental health to ensure nurse well-being and patient safety.

Asunto(s)

RESUMEN

This study aimed to describe sleep quality and explore factors associated with poor sleep quality in Thai intercity bus drivers. A cross-sectional design was employed with a sample of intercity bus drivers from 4 bus transportation companies. The Thai-PSQI was used to identify sleep quality, and the Thai Berlin Questionnaire used to assess sleep apnea risk. Data analysis included descriptive statistics and logistic regression. A total of 338 surveys were analyzed. All bus drivers were male; almost 66% of the bus drivers were defined as poor sleepers, and 18.1% were assessed as being at high risk for obstructive sleep apnea. Working night shifts (OR=20.6), rotating day or night shifts (OR=17.0), alcohol consumption (OR=2.7), being married (OR=3.1), and not exercising (OR=2.3) were related to poor sleep quality. The majority of the Thai intercity bus drivers in our study reported poor sleep quality indicating that action is required at both company and individual levels to encourage the adoption of healthy lifestyles and improvement of working conditions.

Asunto(s)

RESUMEN

OBJECTIVES: This study was conducted to: 1) describe sleep duration, fatigue, daytime sleepiness, and occupational errors among Thai nurses and 2) explore the influence of sleep duration on fatigue, daytime sleepiness, and occupational errors. METHODS: A cross-sectional design was implemented. A convenience sample of 233 full-time nurses with at least one year of work experience was recruited to participate in the study. Data were collected using self-reported questionnaires and 1-week sleep diaries. Descriptive and logistic regression statistics were performed using SPSS software. RESULTS: The mean total sleep time was 6.2 hours. Of the total participants, 75.9% (n=167) experienced short sleep duration, 38.2% (n=84) experienced fatigue, and 49.5% (n=109) experienced excessive daytime sleepiness. Occupational errors were reported by 11.7% (n=25). Medication errors, incorrectly performed procedures, and needle stick injuries were reported by 6.5% (n=13), 5.6% (n=12), and 4.7% (n=10), respectively, of participants performing the associated activities. The "Short Sleep Duration" group experienced more fatigue (p=.044) and excessive daytime sleepiness (p=.001) compared with the "Adequate Sleep Duration" group. Although occupational errors were more common in the "Short Sleep Duration" group, the difference between the two groups did not reach the level of statistical significance. Multivariable logistic regression analysis found that short sleep duration was a statistically significant risk factor for excessive daytime sleepiness (OR=2.47, 95% CI=1.18-5.19). CONCLUSIONS: The majority of registered nurses experience short sleep duration. Short sleep duration increased the risk of excessive daytime sleepiness but not fatigue or occupational errors. Adequate night-time sleep is paramount for preventing daytime sleepiness and achieving optimal work performance.

Asunto(s)

RESUMEN

HIV/AIDS-related stigma has been linked to poor adherence resulting in drug resistance and the failure to control HIV. This study used both quantitative and qualitative methods to examine stigma and its relationship to adherence in 30 HIV-infected Thai youth aged 14 to 21 years. Stigma was measured using the HIV stigma scale and its 4 subscales, and adherence was measured using a visual analog scale. Stigma and adherence were also examined by in-depth interviews. The interviews were to determine whether verbal responses would match the scale's results. The mean score of stigma perception from the overall scale and its 4 subscales ranged from 2.14 to 2.45 on a scale of 1 to 4, indicating moderate levels of stigma. The mean adherence score was .74. The stigma scale and its subscales did not correlate with the adherence. Totally, 17 of the respondents were interviewed. Contrary to the quantitative results, the interviewees reported that the stigma led to poor adherence because the fear of disclosure often caused them to miss medication doses. The differences between the quantitative and the qualitative results highlight the importance of validating psychometric scales when they are translated and used in other cultures.

Asunto(s)