RESUMEN
The clinical usefulness of a hypoallergenic rice (HRS-1) which was produced by enzymatic decomposition of the constituent proteins of original rice was evaluated in a multicentre study in 44 subjects with recalcitrant atopic dermatitis (AD), who were suspected of having rice allergy. The subjects were fed for at least 4 weeks with HRS-1 instead of eliminating both regular rice and wheat from their daily diet. The extent of overall skin lesions was expressed by using the AD affected area and severity index (ADASI). A statistically significant decrease in ADASI was observed at the 2nd and the 4th week readings and at the end of the study. A provocation test with regular rice was carried out in 5 of 44 subjects following the HRS-1 therapy. An obvious increase in ADASI was found in all of these 5 cases just after this procedure. On final evaluation, 77% of the patients tested showed 'moderate' to 'remarkable' improvement, and 59% of the patients a 'moderate' to 'remarkable' reduction in use of the steroid ointment concomitantly used for the treatment. Finally, HRS-1 was evaluated as 'useful' or 'very useful' in 69% of the subjects.
Asunto(s)
Dermatitis Atópica/dietoterapia , Dermatitis Atópica/etiología , Hipersensibilidad a los Alimentos/dietoterapia , Oryza/efectos adversos , Adolescente , Adulto , Niño , Preescolar , Ensayos Clínicos como Asunto , Femenino , Humanos , Lactante , Masculino , Oryza/inmunologíaRESUMEN
The usefulness of hypoallergenic rice (HRS-1) was clinically evaluated in 43 patients with severe atopic dermatitis (AD), who were suspected of having rice allergy, in collaboration with 13 hospitals. The patients were fed with HRS-1 instead of eliminating both regular rice and wheat from their daily diet. AD area and severity index (ADASI) was calculated as an indicator of the degree of cutaneous symptoms. Significant decrease of ADASI were observed in the 2nd and 4th week and at the end of the replacement therapy (5.6 weeks on average). On final evaluation, 74% of the patients tested showed "moderate" to "remarkable" improvement, and in 53% of the patients HRS-1 resulted in a "moderate" to "remarkable" reduction in the dosage and the grade of potency of the steroid ointment concomitantly used for the treatment. Finally, HRS-1 was evaluated as "useful" to "very useful" as the elimination diet in 70% of the patients.
Asunto(s)
Dermatitis Atópica/etiología , Manipulación de Alimentos , Hipersensibilidad a los Alimentos/complicaciones , Oryza/efectos adversos , Adolescente , Adulto , Niño , Dermatitis Atópica/prevención & control , Hipersensibilidad a los Alimentos/prevención & control , HumanosRESUMEN
The total number of mites, and the amount of guanine contained in house dust was determined in samples obtained from homes with and without asthmatic patients in Yokohama City. The data were quantified and their possible association with various factors within the home was examined. The largest number of mites and the greatest amount of guanine were most strongly associated with carpet floor coverings, followed by tatami mats, and then by wooden flooring. A multi-variate analysis revealed that the major factors influencing the number of mites and the amount of guanine in homes were the living room flooring, and the age of the house. Correlation to such living factors ranged from 60 to 70 percent. In the families with asthmatics the frequency of cleaning was an important additional factor. This likely was a result of the strict instructions given by doctors to asthmatic patients. It was shown that the amount of guanine contained in house dust is an indicator of not only the number of mites but also of the amount of allergens contained in home dust.