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1.
J Vet Med Sci ; 83(7): 1113-1119, 2021 Jul 13.
Artículo en Inglés | MEDLINE | ID: mdl-34024871

RESUMEN

One calf died (No. 1) and another was euthanized following astasia (No. 2). Histopathological examination revealed suppurative meningoencephalitis in these calves. Klebsiella pneumoniae antigens were detected in lesions. Thymocytes were decreased in the thymus cortex in both cases. 16S rRNA gene sequencing of the No. 1 isolate and bacterial extracts from formalin fixed paraffin embedded sections of No. 2 revealed that both samples were K. pneumoniae. The No. 1 isolate showed multidrug resistance against penicillin antibiotics, fosfomycin, streptomycin, macrolide antibiotics, tetracycline antibiotics, and clindamycin. Immunosuppression is a significant septicemic K. pneumoniae infection risk factor. Our study provides new aspects regarding K. pneumoniae infections in cattle, bacterial meningoencephalitis differentiation, and K. pneumoniae and bacterial meningoencephalitis treatments.


Asunto(s)
Enfermedades de los Bovinos , Infecciones por Klebsiella , Meningoencefalitis , Animales , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Bovinos , Enfermedades de los Bovinos/tratamiento farmacológico , Farmacorresistencia Bacteriana Múltiple , Infecciones por Klebsiella/tratamiento farmacológico , Infecciones por Klebsiella/veterinaria , Klebsiella pneumoniae , Meningoencefalitis/tratamiento farmacológico , Meningoencefalitis/veterinaria , Pruebas de Sensibilidad Microbiana/veterinaria , ARN Ribosómico 16S/genética
2.
J Vet Diagn Invest ; 32(5): 689-694, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-32715990

RESUMEN

Most of the pigs on a farm in Aichi Prefecture, Japan had chronic diarrhea and severe wasting. The pigs had consumed 8,000 ppm zinc oxide (ZnO) as a feed additive. The pancreas of each of 4 autopsied pigs was less than half the normal size. Acinar cells were considerably decreased. Epithelial duct-like cells were increased and tested positive for cytokeratin AE1/AE3, Ki67, PGP9.5, and Sox9. Pancreatic islet cells were decreased and shrunken. The α and δ cells were relatively decreased, and their distribution was abnormal. Islet cells were positive for PGP9.5. The livers and kidneys had high accumulations of zinc (Zn; 788 µg/g and 613 µg/g, respectively). Copper was deficient in the liver, likely as a result of Zn poisoning. Our immunohistologic examination suggested that the high dose of ZnO could influence the function of islet cells in addition to that of acinar cells. Given that colistin sulfate has been banned as a feed additive in order to reduce antimicrobial use in Japan, the use of ZnO in the livestock industry is expected to increase. Zn supplementation of pig feed must be monitored to prevent Zn poisoning and contamination of soil and water.


Asunto(s)
Pancreatitis Crónica/veterinaria , Enfermedades de los Porcinos/patología , Óxido de Zinc/toxicidad , Crianza de Animales Domésticos , Animales , Cobre/deficiencia , Femenino , Japón , Riñón/química , Hígado/química , Pancreatitis Crónica/inducido químicamente , Pancreatitis Crónica/metabolismo , Pancreatitis Crónica/patología , Sus scrofa , Porcinos , Enfermedades de los Porcinos/inducido químicamente , Enfermedades de los Porcinos/metabolismo , Zinc/envenenamiento , Zinc/toxicidad , Óxido de Zinc/envenenamiento
3.
J Vet Med Sci ; 81(8): 1113-1116, 2019 Aug 09.
Artículo en Inglés | MEDLINE | ID: mdl-31257235

RESUMEN

A 7-day-old calf died following development of mild respiratory symptoms. Postmortem examination revealed the kidneys were inflamed, and Gram-negative bacteria was detected in the kidneys, supporting the diagnosis of suppurative pyelonephritis. Mannheimia varigena antigen was found in the lesions and the cytoplasm of macrophages and neutrophils in the renal cortex. The Gram-negative bacilli from the kidney were identified as M. varigena by sequencing the 16S rDNA. Although M. varigena is known to cause bovine respiratory disease syndrome, shipping fever, and meningitis, it was unknown that it could also cause suppurative pyelonephritis. Our study provides the first evidence of suppurative pyelonephritis caused by M. varigena in cattle and information that would improve our understanding, diagnosis, and treatment for M. varigena infections.


Asunto(s)
Enfermedades de los Bovinos/microbiología , Mannheimia , Infecciones por Pasteurellaceae/veterinaria , Pielonefritis/veterinaria , Animales , Animales Recién Nacidos , Bovinos , Femenino , Infecciones por Pasteurellaceae/mortalidad , Pielonefritis/microbiología
4.
J Vet Med Sci ; 81(2): 274-278, 2019 Feb 28.
Artículo en Inglés | MEDLINE | ID: mdl-30606907

RESUMEN

Five-day-old neonatal piglets presented with debilitation and ananastasia. At the necropsy of one piglet, the apex of the tongue was found to be discolored dark red, and disseminated white foci were found on the cut surface. Many white foci were also found in the lungs and on the serosa of the liver and spleen. Histopathological findings revealed multifocal necrotic glossitis and pneumonia with Gram-negative bacilli. The bacilli were identified as Actinobacillus suis through immunohistochemical, biochemical, and genetic tests, including 16S rRNA gene sequencing. Although A. suis usually causes inflammation in thoracic and abdominal organs, lesions were also found in the tongue in the present case. This study is the first report of glossitis caused by A. suis.


Asunto(s)
Infecciones por Actinobacillus/veterinaria , Actinobacillus suis , Glositis/veterinaria , Sepsis/veterinaria , Infecciones por Actinobacillus/diagnóstico , Infecciones por Actinobacillus/patología , Actinobacillus suis/genética , Animales , Animales Recién Nacidos/microbiología , Glositis/microbiología , Glositis/patología , Necrosis , ARN Ribosómico 16S/genética , Sepsis/diagnóstico , Sepsis/microbiología , Sepsis/patología , Análisis de Secuencia de ARN/veterinaria , Lengua/patología
5.
J Vet Med Sci ; 80(10): 1567-1571, 2018 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-30210095

RESUMEN

A 5-month-old crossbred beef steer died after exhibiting astasia. A postmortem examination revealed verrucous endocarditis and numerous renal hemorrhages. Gram-positive bacteria were identified in the necrotic lesions of the verruca and mitral valve via histopathological analysis. Multifocal necrosis and hemorrhage were detected in the renal cortex. Gram-positive cocci isolated from the verruca were identified via biochemical tests and 16S rRNA gene sequence analysis as Streptococcus suis. Serotyping indicated that the S. suis isolates were untypable, following which these isolates were classified as a new sequence type (ST1000) via multi-locus sequence typing. S. suis is an important pathogen of pigs. However, clinical cases in cattle are rare. This report is intended to provide information that may be useful in the diagnosis of streptococcal disease in cattle.


Asunto(s)
Enfermedades de los Bovinos/microbiología , Endocarditis Bacteriana/veterinaria , Infecciones Estreptocócicas/veterinaria , Streptococcus suis , Animales , Antibacterianos/farmacología , Bovinos , Enfermedades de los Bovinos/patología , Endocarditis Bacteriana/microbiología , Endocarditis Bacteriana/patología , Masculino , Pruebas de Sensibilidad Microbiana , Tipificación Molecular , Tipificación de Secuencias Multilocus , ARN Bacteriano , ARN Ribosómico 16S , Serotipificación , Infecciones Estreptocócicas/microbiología , Infecciones Estreptocócicas/patología , Streptococcus suis/efectos de los fármacos , Streptococcus suis/aislamiento & purificación
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