RESUMEN

Direct asymmetric aldol reaction of aryl ketones with aryl aldehydes catalyzed by chiral metal complex is reported for the first time herein. Two novel semicrown chiral ligands 1a and 1b were synthesized from (S)- and (R)-BINOL, respectively, and then employed to catalyze the direct asymmetric aldol addition of aryl ketones to aryl aldehydes. Introduced with 2.0 equiv of diethylzinc, 1b had higher enantioselectivity than 1a. Up to 97% yield and up to 80% enantioselectivity were achieved.

Asunto(s)

Aldehídos/química , Aldehídos/síntesis química , Cetonas/química , Cetonas/síntesis química , Compuestos Organometálicos/química , Catálisis , Estructura Molecular , Naftoles/química , Estereoisomerismo , Zinc/química