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The presence and distribution of toxic organic compounds in soil pose significant challenges. Whether their distributional characteristics are more complex, especially in arid and semi-arid regions with harsh climatic conditions? This study analyzed the composition, classification, spatial distribution, and sources of 123 toxic organic compounds in 56 soil samples of coal-electricity production base. Those compounds were classified into 11 categories, mainly pesticides (41 compounds), organic synthesis intermediates (31 compounds), and drugs (23 compounds). Seventeen of those compounds were detected over the rate of 30 %, with 13 of them being under the Toxic Substances Control Act (TSCA) inventory. The primary sources of toxic organic compounds were determined using Principal Component Analysis (PCA) and Positive Matrix Factorization (PMF), including the degradation of pesticide residues (22.03 %), emissions of plastic pellets (16.64 %), industrial waste emissions (12.80 %), emissions from livestock (12.74 %), plastic films (11.22 %) and coal-to-liquid projects (10.78 %). This research underscores the widespread presence of toxic organic compounds in soil, highlighting their origins and distribution patterns, which are essential for developing targeted environmental management strategies in arid and semi-arid regions.

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Coal power activities could cause regional fluctuations of trace elements, but the distribution information of these trace elements in arid and semi-arid areas is insufficient. In this study, the soil trace elements (As, B, Be, Cd, Co, Cr, Cu, Fe, Ga, Ge, Mn, Mo, Ni, Pb, Sb, Sn, Sr, Ti, Tl, and Zn) of Ningdong Coal Power Production Base in China were monitored. Results showed that the concentrations of B, Tl, Mn, Pb, Cr, K, Cu, and Co exceeded background values. The maximum risk index reached 265.66, while the trace elements posed a cancer risk to children. Combining correlation analyses (CA), principal component analysis (PCA), and positive matrix factorization (PMF) techniques, it indicated that trace elements were mainly coming from coal combustion (34.15%), livestock farming (17.44%), traffic emissions (12.42%), and natural factors (35.99%). This study reveals the sources and potential ecological risks of soil trace elements in the Ningdong Coal and Power Production Base. It provides a scientific basis for developing targeted environmental management measures and reducing human health risks.

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Ecological remediation with native plants is the main measure to control the pollution of solid waste in Northwest China. However, the heavy metal transport characteristics of these native plants are still unidentified. This study analyzed the distribution of 16 heavy metals in native plants in the desulfurization gypsum yard (DGY), the gangue yard (GY) and the fly ash yard (FAY). The results showed that the soil contained many heavy metals in high concentrations. For instance, As concentrations were comparable to the global soil background values, whereas Cr and Mn concentrations in the area were 2-3 times greater than the global soil background values. The content of heavy metals in the plant root system increased first, then decreased as the distance from the yard increased. Ni, Pb, and Cd migrated well in Artemisia frigida Willd and Artemisia sieversiana Ehrhart ex Willd, with A. sieversiana showing a particularly strong migration in GY. A. sieversiana, on the other hand, was more successful at migrating Cd at DGY and had a similar capability for Mg migration in all three locations. Festuca rubra L was potentially suitable for planting in GY for Ni removal. In conclusion, the migration patterns of different heavy metals were not alike for plants in the three landfills. The results provided a basis for plant selection for ecological restoration in arid and semi-arid regions.

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Ketorolac is a potent nonsteroidal anti-inflammatory drug. Recently, a novel ester of ketorolac, ketorolac pentyl ester, was synthesized. When prepared in injectable oil, the new agent demonstrated a long duration of action. Ketorolac pentyl ester was synthesized using a prodrug design by esterification of ketorolac, and appeared to be a prodrug of ketorolac in vivo, which needed to be confirmed. The aim of the present study was to establish the prodrug's pharmacokinetics in vivo, and to confirm whether or not ketorolac pentyl ester was a prodrug of ketorolac. Pharmacokinetic profiles of intravenous ketorolac and its pentyl ester on an equal-molar basis in six rabbits were evaluated. A high-performance liquid chromatographic method was used to determine the plasma concentrations of ketorolac and its pentyl ester. We found that the plasma concentrations of ketorolac pentyl ester declined rapidly after injection and so did the conversion of ketorolac pentyl ester to ketorolac. Also, the conversion of ketorolac was proved complete when compared with intravenous ketorolac under an equi-molar basis. In conclusion, this in vivo pharmacokinetic study confirmed that keterolac pentyl ester was a prodrug of keterolac.

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