RESUMEN

Class II antigens of the major histocompatibility complex (Ia) are important components in the investigation of cell-mediated immune responses. Several reports have indicated that anti-Ia monoclonal antibodies suppress disease development in animal models. In this paper, the expression of Ia and the effect of anti-Ia on IL-1 secretion from alveolar macrophages (AM) from silica-treated rats was examined. The results obtained showed that 45% of silicotic AM, but only 5% of AM from normal control rats, express Ia antigen. Anti-Ia treatment of silicotic AM reduced IL-1 secretion by 55%. We conclude that anti-Ia immune suppression may involve the inhibition of IL-1 secretion.

Asunto(s)

Antígenos de Histocompatibilidad Clase II , Interleucina-1/metabolismo , Alveolos Pulmonares/inmunología , Silicosis/inmunología , Animales , Anticuerpos Monoclonales/metabolismo , Anticuerpos Monoclonales/farmacología , Terapia de Inmunosupresión , Inmunoterapia , Técnicas In Vitro , Macrófagos/inmunología , Macrófagos/metabolismo , Masculino , Alveolos Pulmonares/metabolismo , Ratas , Ratas Endogámicas , Silicosis/terapia