RESUMEN
A patient with longstanding ulcerative colitis developed an arthropathy of the hands and feet characterized by subluxations at the metacarpophalangeal and metatarsophalangeal joints without apparent osseous erosions. This could be a case of Jaccoud's arthropathy associated with inflammatory bowel disease.
Asunto(s)
Artritis/complicaciones , Enfermedades Inflamatorias del Intestino/complicaciones , Artritis/diagnóstico por imagen , Artritis/patología , Colitis Ulcerosa/complicaciones , Pie/diagnóstico por imagen , Pie/patología , Mano/diagnóstico por imagen , Mano/patología , Humanos , Luxaciones Articulares/complicaciones , Luxaciones Articulares/patología , Masculino , Persona de Mediana Edad , RadiografíaRESUMEN
We describe two patients with rheumatic disease who developed nausea, vomiting, fever and diarrhea after a single dose of azathioprine. Both patients had recurrence of these symptoms upon rechallenge.
Asunto(s)
Azatioprina/efectos adversos , Enfermedades Gastrointestinales/inducido químicamente , Diarrea/inducido químicamente , Femenino , Fiebre/inducido químicamente , Humanos , Persona de Mediana Edad , Náusea/inducido químicamente , Vómitos/inducido químicamenteRESUMEN
The "Arthritis Establishment" is not succeeding in its goal that "every primary and family physician should know criteria for early diagnosis of arthritis, techniques of treatment and when to refer patients for specialized care." The inadequate training of family practice residents in rheumatic diseases is in part responsible for the failure to deliver optimal medical care to the nation's 22 million arthritics.
Asunto(s)
Reumatología/educación , Medicina Familiar y Comunitaria , Humanos , Internado y Residencia , Estados UnidosAsunto(s)
Fascia , Adulto , Eosinófilos , Femenino , Humanos , Inflamación/etiología , Embarazo , Trastornos Puerperales , Factores de TiempoRESUMEN
The unusual occurrence is reported of scleroderma with intestinal involvement in a 59 year old women and her 19 year old nephew. Both died from causes related to this bowel disease.
Asunto(s)
Enfermedades Intestinales/etiología , Esclerodermia Sistémica/genética , Adulto , Estreñimiento/etiología , Femenino , Motilidad Gastrointestinal , Humanos , Obstrucción Intestinal/etiología , Masculino , Persona de Mediana Edad , Esclerodermia Sistémica/complicaciones , Vómitos/etiologíaRESUMEN
Three patients with scleroderma were given intravenous infusions of colchicine (2-4 mg/day) for 3 days. Twenty-four-hour urine collections were assayed for total hydroxyproline (HYPRO), an index of collagen resorption, and for nondialyzable polypeptide HYPRO, an index of collagen synthesis. During the colchicine infusions there was a fall in total urinary HYPRO and a slight increase in the per cent nondialyzalbe HYPRO in each patient. The hydroxylysyl-galactosyl-glucose (HGG) to hydroxylysyl-galactose (HG) ratios were not strikingly different in two samples, with the greastest differences in HYPRO excretion. Our results suggested that total body collagen catabolism had diminished without a concomitant decrease in synthesis. In contrast to provocative reports in the literature, these data do not support the hypothesis that administration of colchicine in doses tolerated in man can either inhibit synthesis of new collagen, increase degradation of mature collagen, or be of use in treatment of fibrotic states.
Asunto(s)
Colchicina/administración & dosificación , Hidroxiprolina/orina , Esclerodermia Sistémica/orina , Adulto , Colchicina/uso terapéutico , Colágeno/biosíntesis , Colágeno/metabolismo , Relación Dosis-Respuesta a Droga , Femenino , Galactosa/metabolismo , Glucosa/metabolismo , Humanos , Infusiones Parenterales , Masculino , Persona de Mediana Edad , Esclerodermia Sistémica/tratamiento farmacológico , VenasRESUMEN
In a kindred of 66 members spanning four generations, seven cases of ankylosing spondylitis (AS) HAVE BEEN FOUND. Four of these were in a single sibship of 13. AS was associated with HL-A27 in three of the four involved siblings, but close linkage was shown to be unlikely. Knowledge of HL-A genotype has made possible informed counseling for younger members of the sibship of 13, some of whom, as teenagers, already have back pain.