RESUMEN

Red blood cells of 17 patients out of seven families diagnosed with HS from the southwest of Poland were studied. In six families a deficiency of ankyrin was detected, and in one family a band 3 (anion-exchanger protein) deficiency was detected. Patients from six families with the ankyrin deficiency had a 19-51% decrease in ankyrin 2.1, while the family with the band 3 deficiency showed a 33% decrease in this protein content. All changes were statistically significant, as analysed by the Student t test (P<0.05). Analysis of haemolysis kinetics gives a reliable indication of altered osmotic properties of the spherocytic cells.

Asunto(s)

Proteína 1 de Intercambio de Anión de Eritrocito/deficiencia , Ancirinas/sangre , Esferocitosis Hereditaria/sangre , Adolescente , Adulto , Ancirinas/deficiencia , Electroforesis de las Proteínas Sanguíneas , Niño , Membrana Eritrocítica/metabolismo , Eritrocitos/química , Familia , Hemólisis , Humanos , Persona de Mediana Edad , Polonia

Asunto(s)

Infarto del Miocardio/epidemiología , Métodos Epidemiológicos , Humanos , Infarto del Miocardio/mortalidad , Polonia