RESUMEN

A bioisosteric carboxamide - sulfonamide replacement explored during the optimization of an insecticide lead compound led to the surprising discovery of a formerly unknown subclass of the Carboxylic Acid Amide (CAA) fungicides, which is the very first CAA fungicide group without a carboxamide function. In this paper we present invention pathway, racemic and stereoselective synthesis routes, structure-activity relationship studies as well as resistance profile of this novel family of fungicides.

Asunto(s)

Fungicidas Industriales/farmacología , Nitrilos/farmacología , Oomicetos/efectos de los fármacos , Sulfonamidas/farmacología , Relación Dosis-Respuesta a Droga , Farmacorresistencia Fúngica/efectos de los fármacos , Fungicidas Industriales/síntesis química , Fungicidas Industriales/química , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Nitrilos/síntesis química , Nitrilos/química , Enfermedades de las Plantas/prevención & control , Estereoisomerismo , Relación Estructura-Actividad , Sulfonamidas/síntesis química , Sulfonamidas/química