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Tissue Antigens ; 55(2): 153-6, 2000 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-10746787

RESUMEN

Here we describe a nucleotide insertion in intron 2 of two rhesus major histocompatibility complex (MHC) class I alleles, Mamu-A*05 and Mamu-A*07. This resulted in an intron 2 that was nearly twice the length of any other intron 2 of primate MHC class I genes sequenced to date. This insertion was most similar (93% identity) to the beginning of intron 3 of HLA-A alleles. It was also similar to intron 3 of several human MHC class I pseudogenes and MHC class I pseudogenes from cotton top tamarin and cat. The finding of this insertion in two rhesus MHC class I genes is surprising given the uniformity in length and sequence of introns of functional HLA-A, -B and -C genes.


Asunto(s)
Alelos , Antígenos de Histocompatibilidad Clase I/genética , Intrones , Secuencia de Aminoácidos , Animales , Secuencia de Bases , ADN Complementario , Humanos , Macaca mulatta , Datos de Secuencia Molecular , Mutagénesis Insercional , Homología de Secuencia de Ácido Nucleico
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