RESUMEN
OBJECTIVE: To evaluate the usefulness and reliability of a research software application for the estimation of an individual's cochlear duct length as a basis for electrode selection. METHODS: In this prospective cohort study, 21 consecutive patients (23 ears) implanted with a cochlear electrode were investigated. The study comprised 19 children (2 bilateral) and 2 adults. RESULTS: The measured 'A' distances (the largest distance from the round window to the contralateral wall) corresponded to cochlear duct lengths of 28.5-36.4 mm. The mean cochlear duct length was 34.05 ± 1.72 mm (33.60 ± 2.27 mm in females and 34.35 ± 1.27 mm in males). Full insertion was achieved in all but two cases. No misplaced electrode array or electrode fold-over was detected. In all but three ears, the electrode was chosen based on the research software application's indication. CONCLUSION: The results show a good correlation between the pre-operatively predicted insertion depths using the software application and those post-operatively measured using X-ray. The insertion length predicted by the software was always longer than that measured via X-ray.
Asunto(s)
Conducto Coclear/diagnóstico por imagen , Implantación Coclear/métodos , Implantes Cocleares , Sordera/cirugía , Ventana Redonda/diagnóstico por imagen , Programas Informáticos , Adulto , Niño , Conducto Coclear/anatomía & histología , Estudios de Cohortes , Femenino , Humanos , Masculino , Tamaño de los Órganos , Estudios Prospectivos , Radiografía , Reproducibilidad de los Resultados , Investigación , Ventana Redonda/anatomía & histología , Hueso Temporal/anatomía & histología , Hueso Temporal/diagnóstico por imagenRESUMEN
This paper presents the synthesis of some tetrazolium salts and metal complexes combinations, which are derived from aromatic and heterocyclic formazans. Elemental quantitative analyses and spectral data confirmed the structure of the new synthesized compounds. The new synthesized compounds were submitted to microbiological tests.
Asunto(s)
Antiinfecciosos/síntesis química , Formazáns/síntesis química , Sales de Tetrazolio/síntesis química , Antibacterianos , Antiinfecciosos/química , Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Candida albicans/efectos de los fármacos , Fenómenos Químicos , Química Física , Formazáns/química , Formazáns/farmacología , Pruebas de Sensibilidad Microbiana/estadística & datos numéricos , Sales de Tetrazolio/química , Sales de Tetrazolio/farmacologíaRESUMEN
This paper presents the synthesis of six hydrazones from isatin and 1-morpholinomethyl-isatin and also of their six cooper's complex salts. Their structure was confirmed by the results of the quantitative elemental analysis and by IR, UV-VIS spectral analysis. The biological tests point out that cooper's complex salt of 3-(3'-phenyl-pyridazinylhydrazono)-5-methyl-indoline-2-one (1:2) (VI a) has the smallest toxicity (DMT over 800 mg/kg.w. p.o.), a remarkable anti-inflammatory activity (inhibition 57.1%, IAR 1.1) and also a gastroprotector coefficient of 43.3%. In the mean time, the cooper's complex salt of 3-(3'-p-anisyl-pyridazinyl-hydrazono)-5-methyl-ind oline-2-one (1:2) (VI b) has a gastroprotector coefficient of 76.3% and a lower anti-inflammatory activity than the first derivative (inhibition 36.9%).
Asunto(s)
Antiinflamatorios/síntesis química , Isatina/análogos & derivados , Piridazinas/síntesis química , Animales , Antiinflamatorios/química , Antiinflamatorios/uso terapéutico , Antiinflamatorios/toxicidad , Carragenina , Evaluación Preclínica de Medicamentos , Edema/inducido químicamente , Edema/tratamiento farmacológico , Femenino , Inflamación/inducido químicamente , Inflamación/tratamiento farmacológico , Isatina/química , Masculino , Ratones , Piridazinas/química , Piridazinas/uso terapéutico , Piridazinas/toxicidadRESUMEN
The paper presents a synthesis of six new Mannich bases, five hydrazones derived from 1-piperidino-methyl-5-R-isatin and three copper complex compounds of 3-(3'-R-phenyl-pyridazinil-hydrazone)-indoline-2-ones (R=H, CH3, OCH3). The structure of the new compounds was confirmed by the results of the elementary and spectral analysis. Pharmacodynamic studies indicated that copper complex compounds present effective biological properties. Thus, it can be seen that the experimental carrageenan-induced inflammatory oedema was 58.3% inhibited by the complex V (R=CH3) after oral administration. Antimicrobial tests revealed that only compound V (R=OCH3) shows a moderate antimicrobial activity against the gram-positive and gram-negative bacteria, used in the test.
Asunto(s)
Hidrazonas/farmacología , Isatina/análogos & derivados , Bases de Mannich/farmacología , Animales , Antibacterianos , Antiinfecciosos/farmacología , Antiinflamatorios/uso terapéutico , Bacterias/efectos de los fármacos , Candida albicans/efectos de los fármacos , Carragenina , Evaluación Preclínica de Medicamentos , Hidrazonas/uso terapéutico , Inflamación/inducido químicamente , Inflamación/tratamiento farmacológico , Isatina/farmacología , Isatina/uso terapéutico , Bases de Mannich/uso terapéutico , Ratones , Pruebas de Sensibilidad Microbiana , Relación Estructura-ActividadRESUMEN
This paper presents a synthesis about some hydrazones, formazans and copper's complexes combinations. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR spectral analysis. The antimicrobial and antiinflammatory activities were investigated.
Asunto(s)
Formazáns/farmacología , Hidrazonas/farmacología , Bacterias/efectos de los fármacos , Candida albicans/efectos de los fármacos , Formazáns/síntesis química , Formazáns/química , Hidrazonas/síntesis química , Hidrazonas/química , Pruebas de Sensibilidad Microbiana/estadística & datos numéricos , Relación Estructura-ActividadRESUMEN
This paper presents the synthesis of six hydrazones obtained by treating 5-methyl-isatin or 1-morpholino methyl-5-methyl-isatin with 3-(R-phenyl)-6-hydrazino-pyridazine (R = OCH3, Cl, Br) and two complex combination with copper, derived from 3-(p-anisyl-pyridazinyl)-hydrazone-5-methyl-indoline-2- one. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR, UV-VIS spectral analysis. The biological tests point out that product VI, in which a copper atom binds two molecules of 3-(p-anisyl-pyridazinyl)-hydrazono-5-methyl-indoline-2-one, has a considerable antiinflammatory activity, giving a inflammation inhibition of 39, 6%. All the synthetized compounds have a moderate antimicrobial activity against Candida albicans.
Asunto(s)
Antiinfecciosos/síntesis química , Antiinflamatorios/síntesis química , Hidrazinas/química , Hidrazonas/síntesis química , Isatina/análogos & derivados , Piridazinas/química , Animales , Antibacterianos , Antiinfecciosos/farmacología , Antiinfecciosos/uso terapéutico , Antiinfecciosos/toxicidad , Antiinflamatorios/farmacología , Antiinflamatorios/uso terapéutico , Antiinflamatorios/toxicidad , Candida albicans/efectos de los fármacos , Carragenina , Fenómenos Químicos , Química Física , Evaluación Preclínica de Medicamentos , Escherichia coli/efectos de los fármacos , Hidrazonas/farmacología , Hidrazonas/uso terapéutico , Hidrazonas/toxicidad , Inflamación/inducido químicamente , Inflamación/tratamiento farmacológico , Isatina/química , Ratones , Staphylococcus aureus/efectos de los fármacos , Relación Estructura-ActividadRESUMEN
The synthesis of ten new heterocyclic compounds obtained by the addition of pyrrolidone to heterocumulenes and its condensation or of its sodic derivative with acid chlorides is presented. The synthetized pyrolidonic derivatives were subjected to a preliminary study for determining their possible psychotropic action. The pharmacological screening evidenced a significant hypothermisante and neurodynamic-nootropic action of some synthetized compounds.
Asunto(s)
Psicotrópicos/síntesis química , Pirrolidinonas/síntesis química , Animales , Sistema Nervioso Central/efectos de los fármacos , Psicotrópicos/química , Psicotrópicos/farmacología , Pirrolidinonas/química , Pirrolidinonas/farmacología , Relación Estructura-ActividadRESUMEN
The methods of obtaining and the physicochemical and spectral characterization of eight new pyridazine derivatives are presented. Thus, the reaction of chlorine-hydrazino-pyridazine with pyruvic and alpha-ketoglutaric acids resulted in the corresponding hydrazones. Using the indications in the literature the tetrazolic, triazolic, pyrazolonic and phenyl-thiocarbazidic derivatives of hydrazino-pyridazine were synthetized. The structure of the new compounds was confirmed by carbon, hydrogen and nitrogen analyses and spectral ones in infrared.
Asunto(s)
Piridazinas/síntesis química , Fenómenos Químicos , Química Física , Piridazinas/química , Piridazinas/farmacología , Relación Estructura-ActividadRESUMEN
The synthesis of eight new 1-(R-pyridazinil)-3-methyl-4-(R-phenylazo)-5-pyrazolone, the structure of which was confirmed by the results of the physicochemical analysis, is presented. The preliminary tests for determining their biological action have revealed a moderate antimicrobial activity.
Asunto(s)
Antiinfecciosos/síntesis química , Pirazoles/síntesis química , Sulfanilamidas/síntesis química , Antibacterianos , Antiinfecciosos/química , Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Candida albicans/efectos de los fármacos , Fenómenos Químicos , Química Física , Pruebas de Sensibilidad Microbiana , Pirazoles/química , Pirazoles/farmacología , Piridinas/síntesis química , Piridinas/química , Piridinas/farmacología , Relación Estructura-Actividad , Sulfanilamidas/química , Sulfanilamidas/farmacología , Tiazoles/síntesis química , Tiazoles/química , Tiazoles/farmacologíaRESUMEN
Further studies in view of obtaining new stable phtalasiniuilides present the synthesis and physico-chemical and biological characterization of certain derivatives obtained through the action of p-phenyl-phenacyl and p-nitro-phenacyl bromides upon R-phtalasine. The structure of the new products was confirmed by physicochemical and spectral analyses. The preliminary biological tests showed a moderate antimicrobial activity of certain studies compounds.