RESUMEN
The absorption of malathion and phosalone was followed in occupationally exposed workers by determination of residues excreted in the urine. Because of the high concentrations found in the morning urine samples, the rates of excretion of phosalone metabolites in the urine of a volunteer experimentally exposed to phosalone during one and then again during three subsequent working days were investigated. The urinary excretion of phosalone metabolites was most intense 4--5 hours after exposure. At the beginning of the next day, the metabolites were still well measureable in the urine. Blood and plasma cholinesterase activities were only slightly reduced during exposure. The analyses of 24-hour urine samples, or of urine samples taken 4--5 hours after exposure, are not suitable for the routine control of occupationally exposed persons because of sampling difficulties. Instead, analyses of samples taken immediately before and after work hours have to be performed. A systematic increase in the concentrations of pesticide residues in the morning urine should initiate more efficient and well-timed protection measures.
Asunto(s)
Malatión/orina , Compuestos Organotiofosforados/orina , Residuos de Plaguicidas/orina , Colinesterasas/sangre , Colinesterasas/orina , Cromatografía de Gases , Exposición a Riesgos Ambientales , Humanos , Malatión/metabolismo , Compuestos Organotiofosforados/metabolismo , Residuos de Plaguicidas/análisis , Factores de TiempoRESUMEN
Plasma or serum samples of 147 individuals from the general population of a continental town in Croatia (Yugoslavia) were analyzed for chlorinated hydrocarbons in 1975. The compounds were determined by gas chromatography and identified by comparing their retention times with those of known standards. All samples contained p,p'-DDE; mean concentration was 35.3 ppb. Only 20 samples contained p,p'-DDT; mean concentration was 22.7 ppb. Concentrations of alpha-BHC, lindane, and p,p'-TDE were 3.25, 4.09, and 11.6 ppb, respectively.