RESUMEN
BACKGROUND: Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin-6 and interleukin-10. Ketoprofen inhibits cyclo-oxygenase activity and hence prostaglandin production. AIM: We hypothesized that ketoprofen would affect release of IL-6 and IL-10 and modulate the immune response. METHOD: We have evaluated 40 women, divided into four groups by the model of postoperative pain treatment: control group (only opioid) and experimental group (combination of i.v. ketoprofen and opioid). Serum IL-6 and IL-10 were measured before surgery, 24 and 72 hours after skin incision. Due to days in hospital we detected temperature and severe complications. RESULTS: IL-6 increased at 24h and normalized at 72h. In contrast IL-10 did not change significantly. CONCLUSION: The two models of postoperative analgesia have both modulated immune response after abdominal hysterectomy in same way.