RESUMEN
During demanding cognitive tasks, older adults (OAs) frequently show greater prefrontal cortex (PFC) activity than younger adults (YAs). This age-related increase in PFC activity is often associated with enhanced cognitive performance, suggesting functional compensation. However, the brain is a complex network of interconnected regions, and it is unclear how network connectivity of PFC regions differs for OAs versus YAs. To investigate this, we examined the age-related difference on the functional brain networks mediating episodic memory retrieval. YAs and OAs participants encoded and recalled visual scenes, and age-related differences in network topology during memory retrieval were investigated as a function of memory performance. We measured both changes in functional integration and reconfiguration in connectivity patterns. The study yielded three main findings. First, PFC regions were more functionally integrated with the rest of the brain network in OAs. Critically, this age-related increase in PFC integration was associated with better retrieval performance. Second, PFC regions showed stronger performance-related reconfiguration of connectivity patterns in OAs. Finally, the PFC reconfiguration increases in OAs tracked reconfiguration reductions in the medial temporal lobe (MTL)-a core episodic memory region, suggesting that PFC connectivity in OAs may be compensating for MTL deficits.
Asunto(s)
Envejecimiento/psicología , Memoria Episódica , Recuerdo Mental/fisiología , Vías Nerviosas/fisiología , Corteza Prefrontal/fisiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Mapeo Encefálico , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Red Nerviosa/diagnóstico por imagen , Red Nerviosa/fisiología , Vías Nerviosas/diagnóstico por imagen , Corteza Prefrontal/diagnóstico por imagen , Desempeño Psicomotor/fisiología , Lóbulo Temporal/diagnóstico por imagen , Lóbulo Temporal/fisiología , Adulto JovenRESUMEN
Aging is often accompanied by associative memory changes, although their precise nature remains unclear. This study examines how recognition of item position in the context of associative memory differs between younger and older adults. Participants studied word pairs (A-B, C-D) and were later tested with intact (A-B), reversed (D-C), recombined (A-D), and recombined and reversed (B-C) pairs. When participants were instructed to respond "Old" to both intact and reversed pairs, and "New" to recombined, and recombined and reversed pairs, older adults showed worse recognition for recombined and reversed pairs relative to younger adults (Experiment 1). This finding also emerged when flexible retrieval demands were increased by asking participants to respond "Old" only to intact pairs (Experiment 2). These results suggest that as conditions for flexible retrieval become more demanding, older adults may show worse recognition in associative memory tasks relative to younger adults.