RESUMEN
The levels of two tumor markers--CEA and CA-19.9 were repeatedly determined in 146 patients with histologically verified colo-rectal cancer and in 58 healthy controls. The normal CA-19.9 values were up to 30 U/ml. The sensitivity of the two markers proved to be low: 48.8 per cent for CEA and 37 per cent for CA-19.9. In 26 of 35 patients with local recurrence or metastases marker increase preceded the appearance of clinical symptoms of progression of the pathologic process. The two markers appeared more informative than each of them when separately determined.
Asunto(s)
Antígenos de Carbohidratos Asociados a Tumores/sangre , Biomarcadores de Tumor/sangre , Antígeno Carcinoembrionario/sangre , Carcinoma/diagnóstico , Neoplasias Colorrectales/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Humanos , Persona de Mediana Edad , Metástasis de la Neoplasia , Recurrencia Local de Neoplasia/diagnóstico , Periodo Posoperatorio , PronósticoAsunto(s)
Carcinoma/patología , Sistema Cardiovascular/patología , Neoplasias Pulmonares/patología , Animales , Carcinoma/inducido químicamente , Neoplasias Pulmonares/inducido químicamente , Ratones , Ratones Endogámicos C57BL , Miocardio/patología , Trasplante de Neoplasias , Neoplasias Experimentales/inducido químicamente , Neoplasias Experimentales/patología , UretanoRESUMEN
The authors examined the changes in the distribution of 3H-noradrenaline in the adrenal glands and serum of white rats-control and experimental-after administration of histamine and ACTH. The results from the experiments revealed characteristic curves of accumulation of 3H-noradrenaline in the adrenal glands of the examined animals, with maximum at the tenth minute and characteristic changes in the activity of the labeled noradrenaline in the adrenals and serum after administration of histamine and ACTH, followed up to the second hour. On the basis of the obtained results from the radiometric examination and from the follow-up of the level of the blood sugar, the authors make inferences for the sequence and character of the processes of incorporation and release of catecholamine from the adrenal glands under the action of ACTH and histamine.