RESUMEN

Extragonadal germ cell tumors are rare neoplasms with histologic features comparable to those of gonadal origin. Squamous cell carcinoma of the esophagus was diagnosed in a 53-year-old male patient, and was palliated for a short period by cisplatin plus 5-fluorouracil. Clinical deterioration and development of gynecomastia led to diagnosis of hormone-secreting choriocarcinoma that originated within the squamous cell tumor of the esophagus. Salvage chemotherapy affected the markers but not the tumor. Extragonadal choriocarcinoma is a chemosensitive tumor, but when arising within squamous cell carcinoma of the esophagus it may be chemoresistant, and lead to a fatal outcome.

Asunto(s)

Carcinoma de Células Escamosas/patología , Coriocarcinoma/patología , Neoplasias Esofágicas/patología , Neoplasias Primarias Múltiples/patología , Biomarcadores de Tumor/análisis , Carcinoma de Células Escamosas/tratamiento farmacológico , Coriocarcinoma/tratamiento farmacológico , Neoplasias Esofágicas/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana Edad , Terapia Recuperativa