1.
Org Biomol Chem
; 17(35): 8067-8070, 2019 09 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-31451812
RESUMEN
Biologically important quinazolinones have been synthesized from 2-aminobenzamides and DMSO. The key feature of the reaction is the utilization of DMSO as a methine source for intramolecular oxidative annulation. The CNS depressant drug methaqualone has also been synthesized by our methodology. The present method involves the synthesis of quinazolinones with a broad substrate scope and a good yield.
2.
Org Lett
; 16(14): 3732-5, 2014 Jul 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24992256
RESUMEN
A Lewis acid catalyzed domino reaction cascades through azide-alkene cycloaddition, rearrangement, aziridine ring opening, and azomethine cycloaddition with a parent dipolarophile, resulting in 3,3'-pyrrolidinyldispirooxindoles containing four contiguous chiral stereocenters with two contiguous quaternary spirostereocenters.